JANA - A NEW ITERATIVE POLYEXPONENTIAL CURVE STRIPPING PROGRAM
JANA - A NEW ITERATIVE POLYEXPONENTIAL CURVE STRIPPING PROGRAM
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DOI：
10.1016/0169-2607(85)90085-9
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发表时间：
1985-01-01
影响因子：
6.1
通讯作者：
DUNNE, A
中科院分区：
文献类型：
--
作者：
DUNNE, A
一种新的迭代多指数曲线剥离技术提供初始药代动力学参数估计已被开发。非线性最小二乘曲线拟合需要这样的估计。与传统的曲线剥离相反，这种新技术不对指数速率常数的相对大小做任何假设。因此，它提供的参数估计是免费的偏见，可能会出现在传统的曲线剥离。已开发了一个BASIC程序JANA来实现新的曲线剥离过程。
A new iterative polyexponential curve stripping technique for the provision of initial pharmacokinetic parameter estimates has been developed. Such estimates are required for nonlinear least-squares curve fitting. In contrast to conventional curve stripping, this new technique does not make any assumption about the relative magnitudes of the exponential rate constants. Hence, the parameter estimates which it provides are free of the bias which may arise in conventional curve stripping. A BASIC program called JANA has been developed to implement the new curve stripping procedure.