Asymmetric Intramolecular C-H Insertion Promoted by Dirhodium(II) Carboxylate Catalyst Axially Chiral Amino Acid Derivatives
Asymmetric Intramolecular C-H Insertion Promoted by Dirhodium(II) Carboxylate Catalyst Axially Chiral Amino Acid Derivatives
复制标题
羧酸二铑(II)催化剂轴向手性氨基酸衍生物促进的不对称分子内C-H插入
DOI：
10.1055/s-0036-1588674
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Lu;W.; Pei;X.;Murai;T.; Sasamori;T.; Tlkitoh;N.; Kawabata;T.; Furuta;T.
制备了一种带有轴向手性氨基酸衍生物的二铑（II）羧酸盐催化剂。X-射线晶体结构分析表明，四个桥联配体在aC 2-bridgery样构象排列。该催化剂在α-芳基-α-重氮乙酸酯不对称插入α-芳基-β-取代的γ-内酯的分子内C-H反应中具有较好的非对映选择性和对映选择性，特别是在苯基和β-萘基取代的底物的反应中。
A dirhodium(II) carboxylate catalyst bearing axially chiral amino acid derivatives is prepared. X-ray crystal structure analysis reveals that four of the bridging ligands are aligned in aC2-symmetry-like conformation. This catalyst is effective in the asymmetric intramolecular C–H insertion of α-aryl-α-diazoacetates to α-aryl-β-substituted γ-lactones with a reasonable level of diastereo- and enantioselectivity, especially in the reaction of phenyl- and β-naphthyl-substituted substrates.