THE EFFECT OF EPHEDRINE IN THE TREATMENT OF MYASTHENIA GRAVIS: SECOND REPORT
THE EFFECT OF EPHEDRINE IN THE TREATMENT OF MYASTHENIA GRAVIS: SECOND REPORT
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麻黄碱治疗重症肌无力的效果：第二份报告
DOI：
10.1001/jama.1933.27420180001007
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发表时间：
1933
期刊：
影响因子：
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通讯作者：
Harriet Edgeworth
中科院分区：
文献类型：
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作者：
Harriet Edgeworth
三年前，我发表了一篇关于在重症肌无力病例中使用麻黄碱的进展的简短报告。与医生和重症肌无力患者的亲属的通信似乎使进一步的报告是可取的。在过去的三年中，除了短期停止使用麻黄碱或增加剂量外，为了实验的目的，我每天服用6/8粒（48毫克）硫酸麻黄碱或盐酸麻黄碱，缓慢但持续地改善。改善的速度显然是一致的；也就是说，过去六个月的改善程度似乎与前六个月一样大。大剂量给我暂时的力量增强，但这些剂量总是在两三个星期后出现这样的不良症状，我总是被迫这样做
Three years ago I 1 published a short report of progress on the use of ephedrine in a case of myasthenia gravis. The correspondence that has developed with physicians and relatives of patients having myasthenia gravis seems to make a further report desirable. In the past three years, except for short periods when the ephedrine has been discontinued or the dose increased, for experimental purposes, I have taken a daily dose of 6/8 grain (48 mg.) of ephedrine sulphate or of ephedrine hydrochloride with slow but continuous improvement. The rate of improvement has been apparently uniform; that is, the amount of improvement during the last six months seems to have been as great as during the first six months. Larger doses give me a temporary increase in strength, but these dosages are invariably followed in two or three weeks by such adverse symptoms that I have always been compelled to