Age-related decrease of the LAMP-2 gene expression in human leukocytes
Age-related decrease of the LAMP-2 gene expression in human leukocytes
复制标题
人类白细胞中 LAMP-2 基因表达与年龄相关的下降
DOI：
10.1016/j.clinbiochem.2012.06.016
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发表时间：
2012-10-01
影响因子：
2.8
通讯作者：
Yan, Bo
中科院分区：
文献类型：
--
作者：
Huang, Jian;Xu, Jing;Yan, Bo
目的：自噬是细胞内一种高度保守的降解途径，参与多种生理过程，与人类衰老相关疾病密切相关。方法：溶酶体相关膜蛋白-2(LAMP-2)蛋白在自噬和伴侣介导的自噬中起关键作用。结果：与40~44岁组相比，65~69岁组外周血白细胞中LAMP-2基因转录水平和蛋白水平显著升高(P
Objective: Autophagy is a highly conserved degradation pathway in cells, which has been involved in many physiological processes and implicated in human age-related diseases. However, autophagy activities have not been systemically investigated with human tissues and cells.Methods: Lysosomal associated membrane protein-2 (LAMP-2) protein is critical for autophagy and chaperone-mediated autophagy. We examined LAMP-2 gene expression and protein levels in the peripheral leukocytes from healthy subjects over 40years old.esults: Compared to those in group of 40-44 years, the LAMP-2 transcript and protein levels in groups of 65-69 (P