BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
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DOI：
10.1016/s1074-7613(00)80199-5
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发表时间：
2000-05-01
期刊：
影响因子：
32.4
通讯作者：
Cyster, JG
中科院分区：
文献类型：
--
作者：
Luther, SA;Lopez, T;Cyster, JG
CXCR 5是B淋巴细胞趋化因子（BLC）的受体，是派伊尔集合淋巴结、腹股沟淋巴结和脾滤泡正常发育所必需的。为了测试BLC在其他淋巴组织分离中的体内活性，产生在胰岛中表达BLC的转基因小鼠。除了吸引B细胞外，BLC表达还导致淋巴结样结构的形成，其中包含B和T细胞区、高内皮微静脉、基质细胞和趋化因子SLC。这些特征的发展强烈依赖于B淋巴细胞和α-光毒素α 1 β 2，并可通过阻断α-光毒素α 1 β 2逆转。这些发现证实BLC足以激活导致有组织淋巴组织形成的事件途径。
CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addition to attracting B cells, BLC expression led to development of lymph node-like structures that contained B and T cell zones, high endothelial venules, stromal cells, and the chemokine SLC. Development of these features was strongly dependent on B lymphocytes and on lymphotoxin alpha 1 beta 2 and could be reversed by blocking lymphotoxin alpha 1 beta 2. These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue.