THREE-COMPONENT REACTION OF TRIPHENYLPHOSPHINE, DIALKYL ACETYLENEDICARBOXYLATE, AND 2-AMINOTHIAZOLE OR 2-AMINOBENZOTHIAZOLE IN THE PRESENCE OF ARYLGLYOXALS: AN EFFICIENT ONE-POT SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRROLES
THREE-COMPONENT REACTION OF TRIPHENYLPHOSPHINE, DIALKYL ACETYLENEDICARBOXYLATE, AND 2-AMINOTHIAZOLE OR 2-AMINOBENZOTHIAZOLE IN THE PRESENCE OF ARYLGLYOXALS: AN EFFICIENT ONE-POT SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRROLES
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DOI：
10.1080/00397911.2010.545496
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发表时间：
2012-01-01
影响因子：
2.1
通讯作者：
Shams, Nasim
中科院分区：
文献类型：
--
作者：
Anary-Abbasinejad, Mohammad;Farashah, Hamidreza Dehghanpour;Shams, Nasim
介绍了一种新的高效的一锅法合成多取代吡咯衍生物的方法，该方法是由二烷基乙酰二甲酸酯、三苯基膦、2-氨基噻唑或2-氨基苯并噻唑在芳基乙醛存在下发生三组分反应合成的。反应在二氯甲烷中进行，反应在室温和中性条件下进行，产物收率较高。
A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction of dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminothiazole or 2-aminobenzothiazole in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded good yields of products.