K, CL, AND H2O ENTRY IN ENDOLYMPH, PERILYMPH, AND CEROBRO-SPINAL FLUID OF THE RAT
K, CL, AND H2O ENTRY IN ENDOLYMPH, PERILYMPH, AND CEROBRO-SPINAL FLUID OF THE RAT
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DOI：
10.1152/ajprenal.1982.243.2.f173
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发表时间：
1982-01-01
影响因子：
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通讯作者：
AMIEL, C
中科院分区：
文献类型：
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作者：
STERKERS, O;SAUMON, G;AMIEL, C
在麻醉和肾切除大鼠静脉注射示踪剂后，研究了放射性K、Cl和H_2O进入内淋巴、外淋巴和CSF的动力学。取耳蜗内淋巴液、前庭阶外淋巴液、鼓阶外淋巴液和脑池脑脊液标本。数据显示如下：内淋巴、外淋巴和CSF中的水快速周转，因为3 H2O在几分钟内与血浆平衡; 42 K和36 Cl缓慢进入外淋巴，因为36 Cl在2小时后与血浆平衡，而42 K在6小时没有平衡; 42 K和36 Cl极缓慢进入内淋巴，因为在实验的5小时内没有获得与血浆的平衡。将这些数据的房室分析与使用外淋巴灌注示踪剂的其他研究的结果进行比较，表明外淋巴而不是血浆可以被认为是内淋巴的前体。
The kinetics of radioactive K, Cl and H2O entry into endolymph, perilymph and CSF were studied after i.v. administration of tracers in anesthetized and nephrectomized rats. Samples of cochlear endolymph, perilymph of scala vestibuli, perilymph of scala tympani and cisternal CSF were obtained. The data showed the following: a rapid turnover of water in endolymph, perilymph and CSF, since 3H2O equilibrated with plasma in a few minutes; a slow entry of 42K and 36Cl in perilymph, since 36Cl equilibrated with plasma after 2 h and 42K did not at 6 h; and an extremely slow entry of 42K and 36Cl in endolymph, since no equilibrium with plasma was obtained within the 5 h of the experiments. The comparison of the compartmental analysis of these data with the results of other studies using perilymphatic perfusion of tracers indicated that perilymph rather than plasma may be considered as the precursor of endolymph.