Dibutyl phthalate, the bioactive compound produced by Streptomyces albidoflavus 321.2
Dibutyl phthalate, the bioactive compound produced by Streptomyces albidoflavus 321.2
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DOI：
10.1016/j.micres.2005.06.007
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发表时间：
2006-01-01
影响因子：
6.7
通讯作者：
Sen, SK
中科院分区：
文献类型：
--
作者：
Roy, RN;Laskar, S;Sen, SK
结果发现，生物活性化合物邻苯二甲酸二丁酯是由一种新的土壤分离菌白黄链霉菌 321.2 产生的。一旦用乙酸乙酯从发酵液中回收该活性化合物，可以分离出13.4mg/l，则通过纸、硅胶柱、薄层和气相色谱法将其纯化。通过分析 UV、IR 和 GC-MS 光谱确定结构。在分析过程中，这种活性化合物对革兰氏阳性和革兰氏阴性细菌以及单细胞和丝状真菌表现出很强的活性。该化合物的抗菌活性被氨基酸脯氨酸逆转。没有观察到急性毒性。 (C) 2005 年爱思唯尔有限公司。版权所有。
It was found that the bioactive compound, dibutyl phthalate, was produced by a new soil isolate Streptomyces albidoflavus 321.2. Once this active compound was recovered by ethyl acetate from the fermented broth, being possible to isolate 13.4 mg/l, it was purified by paper, silica get column, thin layer and gas chromatography. Structure was determined by analysing UV, IR and GC-MS spectra. During analysis, such active compound showed strong activity against Gram-positive and Gram-negative bacteria, as well as unicellular and filamentous fungi. The antimicrobial activity of the compound was reversed by the amino acid proline. No acute toxicity was observed. (C) 2005 Elsevier GmbH. All rights reserved.