T4, T3 and reverse T3 in the plasma of rats during the first 3 months of life.
T4, T3 and reverse T3 in the plasma of rats during the first 3 months of life.
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生命前 3 个月大鼠血浆中的 T4、T3 和反向 T3。
DOI：
10.1530/acta.0.0930448
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
M. P. Ende
中科院分区：
文献类型：
--
作者：
D. van der Heide;M. P. Ende
描述了一种非常灵敏的大鼠血浆反向T3放射免疫测定法。在出生后的前3个月内，测定了雄性和雌性大鼠血浆中T4、T3和反向T3的浓度。当大鼠约16日龄时，T4浓度达到最大值5.2 +/- 0.7 μ g/100 ml（平均值+/- SD）。截至第28天，平均血清T4约为4微克/100 ml。在16-20天期间，T3浓度达到最大值168 +/- 34 ng/100 ml（平均值+/- SD）。约70天后维持约40 ng/100 ml的平台值。对于反向T3，在13至16日龄的大鼠中发现最大值为17.1 +/- 4.2 ng/100 ml（平均值+/- SD），随后在第28天左右急剧下降至8.2 +/- 0.9 ng/100 ml，随后持续缓慢增加。对于T3/反向T3比率（作为转换途径方向的参数），在生命的第四周期间发现最高值16。70天后，T3/反向T3比值仅为3.5。T3和反向T3之间的相互波动，如在人和羊中发现的，在大鼠中不太明显。与T3相比，反向T3的代谢清除率非常高，这可能是原因。
A very sensitive radioimmunoassay for reverse T3 in rat plasma is described. The concentrations of T4, T3 and reverse T3 in plasma of male and female rats were determined during the first 3 months of life. T4 concentrations reached a maximum value of 5.2 +/- 0.7 microgram/100 ml (mean +/- SD) when the rats were about 16 days old. As of day 28 the average serum T4 was approximately 4 microgram/100 ml. Concentrations of T3 reached a maximum value of 168 +/- 34 ng/100 ml (mean +/- SD) during the 16-20 day period. A plateau value of about 40 ng/100 ml was maintained after about 70 days. For reverse T3 a maximum value of 17.1 +/- 4.2 ng/100 ml (mean +/- SD) was found in rats between 13 and 16 days old, followed by a steep decrease to 8.2 +/- 0.9 ng/100 ml around the 28th day and a subsequent continuous slow increase. For the T3/reverse T3 ration (as a parameter of the direction of the conversion pathway) the highest value of 16 was found during the fourth week of life. After 70 days the T3/ reverse T3 ratio was only 3.5. The reciprocal fluctuations between T3 and reverse T3, as found in man and sheep, are less pronounced in the rat. The very high metabolic clearance rate of reverse T3 compared to that of T3 could be the explanation.