Maturation of human central auditory system activity: the T-complex
Maturation of human central auditory system activity: the T-complex
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DOI：
10.1016/s1388-2457(03)00005-1
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发表时间：
2003-04-01
影响因子：
4.7
通讯作者：
Don, M
中科院分区：
文献类型：
--
作者：
Tonnquist-Uhlen, I;Ponton, CW;Don, M
目的：评估和描述一组5~20岁的儿童、青少年和青壮年的听觉诱发电位(AEP)的成熟度。方法：在30个头皮电极位置上测量左耳短串短声诱发的AEP。分析集中在左侧大脑半球颞叶电极T3和T5以及右侧大脑半球T4和T6记录到的T波的年龄相关潜伏期和波幅变化。结果：在5~20岁的14个年龄组的AEP中，T-复合体的活动均表现为T-复合体活动。在电极T3和T4上记录的T-复合体成分在形态和成熟度上都与在T5和T6上记录的不同。与在电极T5和T6测得的AEP潜伏期延长的成熟相反，在电极T3和T4测得的T波成分并没有显示出峰潜伏期随着年龄的变化而发生显著的整体变化。在C3和C4记录到的AEP必需成分PI、NIB和P2与在T5和T6测量到的T波成分之间存在一致的幅度和潜伏期相关性，而在T3和T4处则没有。结论：在记录T波的常用电极上，AEP有不同的成熟模式。在位于更后颞区(T5和T6)的头皮电极上，AEP的特征是延长的成熟模式，与中央电极C3和C4的测量非常相似。这些发现和本文报道的其他发现提供了强有力的证据，证明在电极T5和T6上记录的AEP不是T-络合峰。相反，在更多的前颞叶头皮区域的电极T3和T4上测量的AEP似乎在很大程度上独立于在中央电极位置测量的活动。在这些头皮位置测量到的T波波峰Ta和Tb成熟较早，峰潜伏期总体上没有明显的年龄相关变化。意义：T波波是从颞叶电极T3和T4记录的，代表了次级听觉皮质的活动，比中线电位更好，并且独立于中线电位。它在5-8岁儿童中的强健存在支持了它在评估语言障碍方面的潜在有用性。(C)2003年国际临床神经生理学联合会。爱思唯尔科学爱尔兰有限公司出版。版权所有。
Objective: The purpose of this study was to evaluate and describe the maturation of a set of auditory evoked potentials (AEPs) described as the T-complex from a large group of children, adolescents, and young adults who ranged in age from 5 to 20 years of age.Methods: The AEPs evoked by brief trains of clicks presented to the left ear were measured at 30 scalp-electrode locations. Analyses focused on age-related latency and amplitude changes in the T-complex recorded at the temporal electrode sites T3 and T5 over the left hemisphere and T4 and T6 over the right hemisphere. The maturation of the T-complex components Na, Ta, and Tb was contrasted with those of the obligatory AEPs P-1, N-1b, and P-2 measured at electrodes C3 and C4.Results: T-complex activity was present in the grand average AEPs of all 14 age groups spanning ages 5-20 years. T-complex components recorded at electrodes T3 and T4 differed in both morphology and maturation rate from those recorded at T5 and T6. In contrast to the prolonged maturation of AEP latency measured at electrodes T5 and T6, the T-complex components measured at electrodes T3 and T4 did not show a significant overall change in peak latency as a function of age. Consistent amplitude and latency correlations were found between the obligatory AEP components Pi, Nib and P2 recorded at C3 and C4 and the T-complex components measured at T5 and T6, but not T3 and T4.Conclusions: Distinct patterns of AEP maturation were measured at electrode sites commonly used to record the T-complex. At scalp electrodes located over more posterior temporal areas (T5 and T6), the AEPs were characterized by a prolonged pattern of maturation very similar to that measured at the central electrodes C3 and C4. These findings and others reported in this paper provide strong evidence that the AEPs recorded at electrodes T5 and T6 are not T-complex peaks. In contrast, the AEPs measured at electrodes T3 and T4 over more anterior temporal scalp areas appear largely independent of activity measured at the central electrode locations. The T-complex peaks Ta and Tb measured at these scalp locations mature early, with no overall significant age-related changes in peak latencies.Significance: The T-complex is recorded from the temporal electrodes T3 and T4 represents activity of secondary auditory cortex better than, and independent from, midline potentials. Its robust presence in 5-8 year olds supports its potential usefulness in assessing language impairment. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ireland Ltd. All rights reserved.