Actigraphic evidence for night-time hyperkinesia in Parkinson's disease
Actigraphic evidence for night-time hyperkinesia in Parkinson's disease
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DOI：
10.1080/00207450701591065
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发表时间：
2008-02-01
影响因子：
2.2
通讯作者：
Nass, Robert Daniel
中科院分区：
文献类型：
--
作者：
Nass, Alexander;Nass, Robert Daniel
帕金森氏病是一种常见的运动障碍，不仅导致运动症状，而且还导致自主神经失调、精神变化、感觉障碍和睡眠障碍，如白天嗜睡增加和睡眠碎片。本研究的目的是找出没有运动障碍的个体与帕金森病患者的日间和夜间运动活动水平有何不同。白天和夜间的运动活动水平在17例PD患者和69名对照组进行了测量，连续三天和三夜通过活动记录仪，一种方法，连续长期评估活动水平。计算夜间和日间运动活动之间的比率。PD患者的日间运动活动低1.5-2倍，但夜间运动活动高1.5-2倍。与年轻对照组相比，老年对照组的日间运动活动较低，但夜间运动活动相似。夜间与日间运动活动的比率可以清楚地区分对照组和患者。通过夜间与日间运动活动的比率来区分患者和对照组的可能性值得进一步研究。
Parkinson's disease is a common motor disorder that not only leads to motor symptoms but also autonomic dysregulation, mental changes, sensory disturbances, and sleep disorders such as increased daytime sleepiness and sleep fragmentation. The aim of this study was to find out how the daytime and night-time motor activity levels in individuals without motor disorders differ from patients with Parkinson's disease. Daytime and night-time motor activity levels in 17 PD patients and 69 controls were measured for three consecutive days and nights via actigraphy, a method of continuous long-term assessment of activity levels. A ratio between night-time and daytime motor activity was calculated. PD patients had a 1.5-2-fold lower daytime motor activity but also showed 1.5-2-fold higher motor activity at night time. Older controls showed a lower daytime but similar night-time motor activity when compared to younger controls. A ratio of night-time to daytime motor activity could clearly distinguish controls and patients. The possibility to distinguish patients and controls by the ratio of night-time to daytime motor activity is worth further investigation.