Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case-Control Studies
Association Between the XRCC1 Arg399Gln Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis Based on Case-Control Studies
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XRCC1 Arg399Gln 多态性与头颈癌易感性之间的关联：基于病例对照研究的荟萃分析
DOI：
10.1089/dna.2013.2269
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发表时间：
2014
影响因子：
3.1
通讯作者：
Wang Yajie
中科院分区：
文献类型：
--
作者：
Liu Chuan;Yin Qinghua;Jiao Guangjun;Zhou Xue;Ying Mingzhen;Gao Wei;Hu Jiangbing;Wei Li;Wang Ning;Wang Yajie
关于XRCC 1Arg 399 Gln多态性与头颈癌（HNC）易感性之间的关联的已发表数据显示不一致的结果。对符合条件的文献进行荟萃分析，以得出更精确的关系估计。我们系统地检索了PubMed、Embase和Web of Science，时间限制为2013年10月28日。采用随机效应模型，以总优势比（OR）和95%CI评估XRCC 1Arg 399 Gln多态性与HNC易感性的关联强度。共纳入27项病例对照研究进行分析，包括5942例病例和9041例对照。Meta分析显示，XRCC 1Arg 399 Gln变异携带者对HNC不敏感（AA与GG：OR=0.92，95% CI=0.77-1.11; AG与GG：OR=1.05，95% CI=0.76-1.44;显性模型AA+AG与GG：OR=1.00，95% CI =0.78-1.29;隐性模型AA与AG+GG：OR=1.00，95% CI=0.78-1.29）OR=0.91，95%CI =0.71-1.16）。此外，按种族和对照来源进行的亚组分析未发现任何人群中XRCC 1Arg 399 Gln多态性与头颈部易感性有任何显著相关性。Meta分析提示XRCC 1Arg 399 Gln多态性不是HNC易感性的危险因素。
Published data regarding the association between theXRCC1Arg399Gln polymorphism and head and neck cancer (HNC) susceptibility showed inconsistent results. This meta-analysis of eligible literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, and Web of Science with a time limit of Oct 28, 2013. Summary odds ratios (ORs) with 95% CIs were used to assess the strength of association betweenXRCC1Arg399Gln polymorphism and HNC susceptibility using random-effect model. A total of 27 case–control studies including 5942 cases and 9041 controls were included for analysis. Meta-analysis of total studies showed that theXRCC1Arg399Gln variant carriers were not susceptible to HNC (AA vs. GG: OR=0.92, 95% CI=0.77–1.11; AG vs. GG: OR=1.05, 95% CI=0.76–1.44; the dominant model AA+AG vs. GG: OR=1.00, 95% CI=0.78–1.29; the recessive model AA vs. AG+GG: OR=0.91, 95% CI=0.71–1.16). Further, subgroup analyses by ethnicity and source of controls did not identify any significant associations ofXRCC1Arg399Gln polymorphism with head and neck susceptibility in any populations. Our meta-analysis suggested that theXRCC1Arg399Gln polymorphism was not a risk factor for HNC susceptibility.