A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents.
A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents.
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DOI：
10.1016/j.tube.2015.07.001
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Lindestam Arlehamn CS
中科院分区：
文献类型：
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作者：
Carpenter C;Sidney J;Kolla R;Nayak K;Tomiyama H;Tomiyama C;Padilla OA;Rozot V;Ahamed SF;Ponte C;Rolla V;Antas PR;Chandele A;Kenneth J;Laxmi S;Makgotlho E;Vanini V;Ippolito G;Kazanova AS;Panteleev AV;Hanekom W;Mayanja-Kizza H;Lewinsohn D;Saito M;McElrath MJ;Boom WH;Goletti D;Gilman R;Lyadova IV;Scriba TJ;Kallas EG;Murali-Krishna K;Sette A;Lindestam Arlehamn CS
我们比较了来自不同HLA分布、结核分枝杆菌暴露率和结核病治疗标准的9个地区和人群中潜伏感染结核分枝杆菌（LTBI）的个体和以前接种过卡介苗的未感染个体对59种普遍识别的结核分枝杆菌（MTB）抗原的T细胞识别。该比较显示，在不同的LTBI和bcg接种队列中，相似的应答幅度，并且美国和其他地区的LTBI应答之间存在显著相关性。许多抗原被统一识别，表明适合纳入针对不同人群的疫苗。几种抗原在LTBI和BCG队列中具有相似的免疫优势，这表明旨在增强BCG应答的疫苗的适用性。MTB抗原组将对表征MTB特异性CD4 T细胞反应具有价值，而不考虑种族、感染MTB菌株和卡介苗接种状况。我们的研究结果说明了比较分析如何能够深入了解ltbi中现有和新型候选疫苗的相对免疫原性。
We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.