Brain mechanisms underlying cue-based memorizing during free viewing of movie Memento
Brain mechanisms underlying cue-based memorizing during free viewing of movie Memento
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DOI：
10.1016/j.neuroimage.2018.01.068
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发表时间：
2018-05-15
期刊：
影响因子：
5.7
通讯作者：
Tikka, Pia
中科院分区：
文献类型：
--
作者：
Kauttonen, Janne;Hlushchuk, Yevhen;Tikka, Pia
人脑如何回忆相关记忆并将其与正在展开的事件联系起来？为了研究这一点，我们让25名健康受试者在功能磁共振成像期间观看电影《记忆》(导演C.Nolan)。在这部电影中，场景按时间顺序逆序呈现，某些场景短暂地与之前呈现的场景重叠。这种重叠的关键帧为观众提供了有效的记忆线索，促使他们回忆起之前看到的场景的相关记忆，并将它们与当前场景联系起来。我们假设，这些重复的关键帧作为即时回忆线索，将有助于故事的逐段重建。在另一组受试者的单独实验中显示的按时间顺序排列的Memento版本作为对照条件。利用多变量事件相关模式分析方法和表征相似性分析方法，发现在关键帧场景的呈现过程中出现了血流动力学活动的焦点指纹模式。这种效应存在于较高级的皮质网络中，包括楔前回、角回、扣带回，以及额叶内的外侧、上、中回。这个网络是右半球占优势的。这些大脑活动的分布模式似乎是回忆相关记忆并将它们与正在进行的事件联系起来的能力的基础，即复杂故事中的“什么与什么相伴”。鉴于电影体验与现实生活的相似之处，这些结果为人类大脑如何在适当的线索下回忆相关记忆提供了新的见解，以促进对日常生活事件的理解和预测。
How does the human brain recall and connect relevant memories with unfolding events? To study this, we presented 25 healthy subjects, during functional magnetic resonance imaging, the movie 'Memento' (director C. Nolan). In this movie, scenes are presented in chronologically reverse order with certain scenes briefly overlapping previously presented scenes. Such overlapping "key-frames" serve as effective memory cues for the viewers, prompting recall of relevant memories of the previously seen scene and connecting them with the concurrent scene. We hypothesized that these repeating key-frames serve as immediate recall cues and would facilitate reconstruction of the story piece-by-piece. The chronological version of Memento, shown in a separate experiment for another group of subjects, served as a control condition. Using multivariate event-related pattern analysis method and representational similarity analysis, focal fingerprint patterns of hemodynamic activity were found to emerge during presentation of key-frame scenes. This effect was present in higher-order cortical network with regions including precuneus, angular gyrus, cingulate gyrus, as well as lateral, superior, and middle frontal gyri within frontal poles. This network was right hemispheric dominant. These distributed patterns of brain activity appear to underlie ability to recall relevant memories and connect them with ongoing events, i.e., "what goes with what" in a complex story. Given the real-life likeness of cinematic experience, these results provide new insight into how the human brain recalls, given proper cues, relevant memories to facilitate understanding and prediction of everyday life events.