New antifungal strategies: drug combination and co-delivery.
New antifungal strategies: drug combination and co-delivery.
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DOI：
10.1016/j.addr.2023.114874
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发表时间：
2023-05
影响因子：
16.1
通讯作者：
P. Zhu;Yan Li;Ting Guo;Simei Liu;Robert J Tancer;Changhua Hu;Chengzhi Zhao;C. Xue;G. Liao
中科院分区：
文献类型：
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作者：
P. Zhu;Yan Li;Ting Guo;Simei Liu;Robert J Tancer;Changhua Hu;Chengzhi Zhao;C. Xue;G. Liao
侵袭性真菌感染的日益增多和耐药率的上升对人类健康构成了重大威胁。抗真菌药物组合因其提高治疗效果、减少药物剂量、逆转或改善耐药性的潜力而引起了人们的极大兴趣。彻底了解抗真菌药物耐药性和药物组合的分子机制是开发新药物组合的关键。在这里，我们讨论抗真菌药物耐药性的机制，并阐明如何发现有效的药物组合来克服耐药性。我们还研究了开发此类组合所遇到的挑战并讨论了前景，包括先进的药物输送策略。
The growing occurrence of invasive fungal infections and the mounting rates of drug resistance constitute a significant menace to human health. Antifungal drug combinations have garnered substantial interest for their potential to improve therapeutic efficacy, reduce drug doses, reverse, or ameliorate drug resistance. A thorough understanding of the molecular mechanisms underlying antifungal drug resistance and drug combination is key to developing new drug combinations. Here we discuss the mechanisms of antifungal drug resistance and elucidate how to discover potent drug combinations to surmount resistance. We also examine the challenges encountered in developing such combinations and discuss prospects, including advanced drug delivery strategies.