Structural and Functional Changes Are Related to Cognitive Status in Wilson's Disease.
Structural and Functional Changes Are Related to Cognitive Status in Wilson's Disease.
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威尔逊氏病的结构和功能改变与认知状态有关。
DOI：
10.3389/fnhum.2021.610947
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发表时间：
2021
影响因子：
2.9
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Hu S;Xu C;Dong T;Wu H;Wang Y;Wang A;Kan H;Li C
威尔逊病（WD）患者患有前瞻性记忆（PM）障碍，其中一些患者出现认知障碍。然而，很少有人知道大脑结构和功能的变化如何影响WD的PM。在这里，我们采用多模态神经影像数据采集22 WD患者和26名健康对照（HC）进行三维T1加权，扩散张量成像（DTI），静息状态功能磁共振成像（RS-fMRI）。我们研究了灰质（GM）体积与体素为基础的形态学，DTI指标使用纤维束成像方法，和RS-fMRI使用种子为基础的功能连接方法。与HC相比，WD患者显示基底节（BG）和枕梭状回的GM体积减少，以及视觉联合皮层的体积增加。此外，WD的白质（WM）轨迹广泛受损的协会和边缘纤维。WD患者联合纤维中的WM轨迹与PM显著相关。相对于HC，WD患者显示视觉关联皮层与丘脑和海马功能性连接，这与WD患者的整体认知功能相关。总之，这些研究结果表明，PM损害WD可能是由异常的WM关联纤维调制，并在关联皮层GM体积的变化对认知状态没有直接影响，但间接影响全球认知功能的异常功能连接（FC）的WD患者。本研究为进一步研究WD发展为认知障碍的机制提供了新的窗口，加深了对WD认知状态和神经病理的认识。
Patients with Wilson’s disease (WD) suffer from prospective memory (PM) impairment, and some of patients develop cognitive impairment. However, very little is known about how brain structure and function changes effect PM in WD. Here, we employed multimodal neuroimaging data acquired from 22 WD patients and 26 healthy controls (HC) who underwent three-dimensional T1-weighted, diffusion tensor imaging (DTI), and resting state functional magnetic resonance imaging (RS-fMRI). We investigated gray matter (GM) volumes with voxel-based morphometry, DTI metrics using the fiber tractography method, and RS-fMRI using the seed-based functional connectivity method. Compared with HC, WD patients showed GM volume reductions in the basal ganglia (BG) and occipital fusiform gyrus, as well as volume increase in the visual association cortex. Moreover, whiter matter (WM) tracks of WD were widely impaired in association and limbic fibers. WM tracks in association fibers are significant related to PM in WD patients. Relative to HC, WD patients showed that the visual association cortex functionally connects to the thalamus and hippocampus, which is associated with global cognitive function in patients with WD. Together, these findings suggested that PM impairment in WD may be modulated by aberrant WM in association fibers, and that GM volume changes in the association cortex has no direct effect on cognitive status, but indirectly affect global cognitive function by its aberrant functional connectivity (FC) in patients with WD. Our findings may provide a new window to further study how WD develops into cognitive impairment, and deepen our understanding of the cognitive status and neuropathology of WD.
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DOI：
10.1016/s1474-4422(14)70190-5
发表时间：
2015-01
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Bandmann O;Weiss KH;Kaler SG
通讯作者：
Kaler SG
影响因子：
19.9
作者：
Bridge H;Leopold DA;Bourne JA
通讯作者：
Bourne JA
白质微观结构变化导致 2 型糖尿病患者认知功能恶化
影响因子：
7.7
作者：
Gao, Shudan;Chen, Yaojing;Zhang, Zhanjun
通讯作者：
Zhang, Zhanjun
影响因子：
5.7
作者：
Graham, Mark S.;Drobnjak, Ivana;Zhang, Hui
通讯作者：
Zhang, Hui
星形胶质细胞功能和神经回路中表型的多样性。
影响因子：
25
作者：
Khakh BS;Sofroniew MV
通讯作者：
Sofroniew MV