Distinct regions of the striatum underlying effort, movement initiation and effort discounting.
Distinct regions of the striatum underlying effort, movement initiation and effort discounting.
复制标题
纹状体的不同区域是努力、运动启动和努力折扣的基础。
DOI：
10.1038/s41562-020-00972-y
复制
发表时间：
2021-03
影响因子：
29.9
通讯作者：
Treadway MT
中科院分区：
文献类型：
--
作者：
Suzuki S;Lawlor VM;Cooper JA;Arulpragasam AR;Treadway MT
腹侧纹状体被认为编码了成本/收益选项的主观价值；然而，在涉及体力努力的选择中，这种影响明显缺失。先前在自由活动的动物身上的研究揭示了相反的纹状体信号，对不断增加的努力需求的反应更大，对需要努力的奖励的反应更少。然而，这些相互矛盾的信号之间的关系仍不得而知。使用自然主义迷宫导航范式的功能磁共振成像，我们识别了腹侧纹状体中功能分离的区域，这些区域分别编码努力激活、运动启动和奖励的努力折扣。此外，在基于努力的决策中，与努力激活和折扣相关的区域的活动相反地预测了努力的纹状体编码。我们的结果表明，迄今为止与动作相关的背内侧区域可能代表了努力的成本，并提出了关于在努力要求的背景下解释纹状体“奖励”信号的基本问题。这对揭示动机行为背后的神经结构具有重要意义。
The ventral striatum is believed to encode the subjective value of cost/benefit options; however, this effect has notably been absent during choices that involve physical effort. Prior work in freely-moving animals has revealed opposing striatal signals, with greater response to increasing effort demands and reduced responses to rewards requiring effort. Yet, the relationship between these conflicting signals remains unknown. Using fMRI with a naturalistic maze-navigation paradigm, we identified functionally-segregated regions within ventral striatum that separately encoded effort activation, movement initiation, and effort discounting of rewards. Additionally, activity in regions associated with effort activation and discounting oppositely predicted striatal encoding of effort during effort-based decision-making. Our results suggest that the dorsomedial region hitherto associated with action may instead represent the cost of effort, and raises fundamental questions regarding the interpretation of striatal “reward” signals in the context of effort demands. This has implications for uncovering the neural architecture underlying motivated behavior.
登录
查看更多内容
影响因子：
9.8
作者：
Chong TT;Apps M;Giehl K;Sillence A;Grima LL;Husain M
通讯作者：
Husain M
影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
影响因子：
2.5
作者：
Gregorios-Pippas L;Tobler PN;Schultz W
通讯作者：
Schultz W
影响因子：
9.8
作者：
Gorgolewski, Krzysztof J.;Mendes, Natacha;Wilfling, Domenica;Wladimirow, Elisabeth;Gauthier, Claudine J.;Bonnen, Tyler;Ruby, Florence J. M.;Trampel, Robert;Bazin, Pierre-Louis;Cozatl, Roberto;Smallwood, Jonathan;Margulies, Daniel S.
通讯作者：
Margulies, Daniel S.
影响因子：
5.7
作者：
Abler, Birgit;Walter, Henrik;Spitzer, Manfred
通讯作者：
Spitzer, Manfred