Inspiratory resistance maintains arterial pressure during central hypovolemia: Implications for treatment of patients with severe hemorrhage
Inspiratory resistance maintains arterial pressure during central hypovolemia: Implications for treatment of patients with severe hemorrhage
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DOI：
10.1097/01.ccm.0000259464.83188.2c
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发表时间：
2007-04-01
影响因子：
8.8
通讯作者：
Lurie, Keith G.
中科院分区：
文献类型：
--
作者：
Convertino, Victor A.;Ryan, Kathy L.;Lurie, Keith G.
Objective: To test the hypothesis that an impedance threshold device would increase systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure and delay the onset of symptoms and cardiovascular collapse associated with severe central hypovolemia.Design., Prospective, randomized, blinded trial design.Setting. Human physiology laboratory.Patients: Nine healthy nonsmoking normotensive subjects (five males, four females).Interventions: Central hypovolemia and impending cardiovascular collapse were induced in human volunteers by applying progressive lower body negative pressure (under two experimental conditions: a) while breathing with an impedance threshold device set to open at -7 cm H2O pressure (active impedance threshold device); and b) breathing through a sham impedance threshold device (control).Measurements and Main Results: Systolic blood pressure (79 5 mm Hg), diastolic blood pressure (57 3 mm Hg), and mean arterial pressure (65 +/- 4 mm Hg) were lower (p
