Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C
Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C
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DOI：
10.1017/s1355617707070877
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发表时间：
2007-07-01
影响因子：
2.6
通讯作者：
Fontana, Robert J.
中科院分区：
文献类型：
--
作者：
Bieliauskas, Linas A.;Back-Madruga, Carla;Fontana, Robert J.
本研究评估了198例丙型肝炎病毒感染患者的认知储备对神经心理测试表现的影响。将智商分数、教育水平和职业等级结合起来计算每名患者的认知储备分数（CRS）。类似于人类免疫缺陷病毒感染的研究。在具有较低CRS的个体中，神经心理测试表现受损的风险显著增加。在大规模临床试验中评估认知结果时，考虑CRS是很重要的。
This study evaluated the influence of cognitive reserve on neuropsychological test performance in 198 patients infected with the hepatitis C Virus. IQ scores, educational level, and occupational rating were combined to calculate a Cognitive Reserve Score (CRS) for each patient. Similar to studies of infection with the human immunodeficiency virus. there was a significantly increased risk of impairment in neuropsychological test performance in individuals with lower CRSs. It is important to account for CRS when assessing cognitive findings in large-scale clinical trials.