Small-animal X-ray dose from micro-CT.
Small-animal X-ray dose from micro-CT.
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DOI：
10.1162/1535350042380326
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发表时间：
2004-07-01
影响因子：
2.8
通讯作者：
Cherry, Simon R
中科院分区：
文献类型：
--
作者：
Boone, John M;Velazquez, Orlando;Cherry, Simon R
近年来，微型CT在小动物中的使用有所增加。虽然用于微CT的辐射水平通常不会对动物致命，但它们足够高，免疫反应和其他生物途径的变化可能会改变实验结果。因此，了解特定成像程序的剂量非常重要。采用Monte Carlo模拟法评价X射线照射对小动物（直径5 - 40 mm）的辐射剂量。单能（6 - 100 keV）和多能（15 - 100 kVp）的X射线源进行了模拟下典型的小鼠成像几何形状。使用市售的X射线光谱仪在小鼠成像X射线系统上进行X射线光谱测量，并且也使用来自高能系统的光谱。对于一个典型的X射线系统，在40 kVp时添加1.0 mm的Al，对于直径为10、20、30和40 mm的小鼠，剂量系数（在等中心处每个空气比释动能对小鼠的剂量）分别为0.80、0.63、0.52和0.44 mGy/mGy。提供了许多表格和图，用于在一系列小鼠成像几何形状上进行剂量估计。
The use of micro-CT in small animals has increased in recent years. Although the radiation levels used for micro-CT are generally not lethal to the animal, they are high enough where changes in the immune response and other biological pathways may alter the experimental outcomes. Therefore, it is important to understand what the doses are for a specific imaging procedure. Monte Carlo simulation was used to evaluate the radiation dose to small animals (5-40 mm in diameter) as a result of X-ray exposure. Both monoenergetic (6-100 keV) and polyenergetic (15-100 kVp) X-ray sources were simulated under typical mouse imaging geometries. X-ray spectral measurements were performed on a mouse imaging X-ray system using a commercially available X-ray spectrometer, and spectra from high-energy systems were used as well. For a typical X-ray system with 1.0 mm of added Al at 40 kVp, the dose coefficients (dose to mouse per air kerma at isocenter) were 0.80, 0.63, 0.52, and 0.44 mGy/mGy for mouse diameters of 10, 20, 30, and 40 mm, respectively. A number of tables and figures are provided for dose estimation over a range of mouse imaging geometries.