Short report: Vaccination of pigs to control human neurocysticercosis
Short report: Vaccination of pigs to control human neurocysticercosis
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DOI：
10.4269/ajtmh.2005.72.837
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Lightowlers, MW
中科院分区：
文献类型：
--
作者：
Gonzalez, AE;Gauci, CG;Lightowlers, MW
猪带绦虫病/囊尾蚴病是一种人畜共患疾病，猪是其中的专性中间宿主。这种感染很普遍，特别是在发展中国家，神经囊尾蚴病是人类神经系统疾病的主要原因，这种寄生虫在这些地区流行。尽管很容易获得，但有效的抗寄生虫药物尚未有效地用于控制疾病传播。我们研究了预防猪中间宿主寄生虫感染的疫苗策略。这样的策略将中断寄生虫的生命周期并消除人类的感染源。在口服猪带绦虫卵的猪身上进行了疫苗接种试验，测试了从寄生虫甲蚴生命周期阶段选择的两种重组抗原。两种抗原都非常有效地保护猪免受寄生虫感染（分别为 98.6% 和 99.9% 的保护）。在接种了其中一种抗原的八头猪中没有发现存活的包囊。基于甲蚴抗原的重组亚单位疫苗有可能改善猪丝虫的现有控制措施，从而减少或消除神经囊尾蚴病。
Taenia solium taeniasis/eysticercosis is a zoonotic disease complex in which the pig is an obligate intermediate host. The infection is widespread, particularly in the developing world, and neurocysticercosis is a major cause of human neurologic disease where the parasite is endemic. Despite easy availability, effective anti-parasitic drugs have not been deployed effectively to control disease transmission. We have investigated a vaccine strategy to prevent parasite infection of the pig intermediate host. Such a strategy would interrupt the parasite's life cycle and eliminate the source of infection for humans. Two recombinant antigens selected from the parasite oncosphere life cycle stage were tested in vaccination trials in pigs that were challenged orally with Taenia solium eggs. Both antigens were highly effective in protecting, the pigs against infection with the parasite (98.6% and 99.9% protection, respectively). No viable cysts were found in eight pigs vaccinated with one of the antigens. A recombinant subunit vaccine based on oncosphere antigens has the potential to improve the available control measures for T. solium and thereby reduce or eliminate neurocysticercosis.