Vertebral morphometric X-ray absorptiometry in women with Colles' fracture
Vertebral morphometric X-ray absorptiometry in women with Colles' fracture
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DOI：
10.1385/jcd:6:4:359
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发表时间：
2003-12-01
影响因子：
2.5
通讯作者：
Carbonell, J
中科院分区：
文献类型：
--
作者：
Kanterewicz, E;Yañez, A;Carbonell, J
年轻绝经后妇女的Colles骨折（CF）与低骨矿物质密度（BMD）和其他骨质疏松性骨折的风险增加有关;然而，尚未研究CF患者椎体畸形的患病率。双能X线骨密度仪（DXA）椎体形态测量（MXA）是一种用于评估椎体畸形的研究工具，但其临床应用仍然有限。这项工作的目的是了解CF女性椎体畸形的患病率，研究身高比的形态学特征，并确定MXA结果与BMD之间的相关性。在一项事件病例对照研究中对MXA进行了评价，该研究招募了58名近期CF女性和83名基于人群的对照女性。测量前部（Ha）、中部（Hm）和后部（Hp）高度，并计算楔形（Ha/Hp）和中部楔形（Hm/Hp）比值。当任何椎体节段至少有一个比率低于该比率的参考平均值3 SD时，定义为椎体畸形。病例组平均年龄65.8岁，对照组平均年龄58.7岁（P < 0.05）。在19%的病例和11%的对照组中发现了形态测量的椎体畸形（无显著性）。在每个椎体节段，病例组的中楔比低于对照组（p < 0.05），而楔比结果未显示出显著性结果。当样本按年龄分层时，CF显示出仅在年轻人中与椎体畸形相关的趋势（
Colles' fracture (CF) in younger postmenopausal women is associated with low bone mineral density (BMD) and with an increased risk of other osteoporotic fractures; however, the prevalence of vertebral deformities has been not studied in CF patients. Vertebral morphometry (MXA) using dual-energy X-ray absorptiometry (DXA) is a research tool developed to evaluate the presence of vertebral deformities, but its clinical use is still limited. The goals of this work were to know the prevalence of vertebral deformities in women with CF, to study the morphometric characteristics of height ratios, and to determine the correlation between MXA findings and BMD. MXA was evaluated within an incident case-control study in which 58 women with a recent CF and 83 population-based control women were enrolled. Anterior (Ha), middle (Hm), and posterior (Hp) heights were measured, and wedge (Ha/Hp) and mid-wedge (Hm/Hp) ratios were calculated. A vertebral deformity was defined when at least one ratio fell 3 SD below the reference mean of that ratio at any vertebral level. The mean age of cases was 65.8 yr and in controls 58.7 (p < 0.05). Morphometric vertebral deformities were found in 19% of cases against 11% of controls (nonsignificant). The cases had a lower mid-wedge ratio than controls at each vertebral level (p < 0.05), while wedge ratio results did not show significant results. When the sample was stratified by age, CF showed a trend to be associated with vertebral deformity only in the younger (