Biological aspects of early osteoarthritis
Biological aspects of early osteoarthritis
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DOI：
10.1007/s00167-011-1705-8
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发表时间：
2012-03-01
影响因子：
3.8
通讯作者：
Facchini, Andrea
中科院分区：
文献类型：
--
作者：
Madry, Henning;Luyten, Frank P.;Facchini, Andrea
早期骨关节炎主要影响关节软骨，累及整个关节，包括软骨下骨、滑膜、半月板和关节周围结构。这篇综述的目的是强调早期OA的分子基础和组织病理学特征。选择性文献综述。发生早期骨关节炎的危险因素包括但不限于遗传易感性、机械因素（如轴向失调）和衰老。早期骨性关节炎，关节软骨表面逐渐不连续，表现为纤维性颤动和垂直裂缝，延伸不深于关节软骨中间区，反映OARSI等级1.0-3.0。软骨下骨的早期变化包括软骨下板和关节下海绵厚度的逐渐增加。早期骨关节炎不仅影响关节软骨和软骨下骨，还影响关节的其他结构，如半月板、滑膜、关节囊、韧带、肌肉和髌下脂肪垫。遗传标记或标记组合在未来可能对识别早期OA和高危患者有用。OA的高社会经济影响表明，更好地了解早期OA的机制可能是在疾病的第一阶段开发更有针对性的重建治疗的关键。系统评价，二级。
Early OA primarily affects articular cartilage and involves the entire joint, including the subchondral bone, synovial membrane, menisci and periarticular structures. The aim of this review is to highlight the molecular basis and histopathological features of early OA.Selective review of literature.Risk factors for developing early OA include, but are not limited to, a genetic predisposition, mechanical factors such as axial malalignment, and aging. In early OA, the articular cartilage surface is progressively becoming discontinuous, showing fibrillation and vertical fissures that extend not deeper than into the mid-zone of the articular cartilage, reflective of OARSI grades 1.0-3.0. Early changes in the subchondral bone comprise a progressive increase in subchondral plate and subarticular spongiosa thickness. Early OA affects not only the articular cartilage and the subchondral bone but also other structures of the joint, such as the menisci, the synovial membrane, the joint capsule, ligaments, muscles and the infrapatellar fat pad. Genetic markers or marker combinations may become useful in the future to identify early OA and patients at risk.The high socioeconomic impact of OA suggests that a better insight into the mechanisms of early OA may be a key to develop more targeted reconstructive therapies at this first stage of the disease.Systematic review, Level II.