Liver cysts in autosomal-dominant polycystic kidney disease: clinical and computed tomographic study.
Liver cysts in autosomal-dominant polycystic kidney disease: clinical and computed tomographic study.
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常染色体显性多囊肾病中的肝囊肿：临床和计算机断层扫描研究。
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
J. Grantham
中科院分区：
文献类型：
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作者：
E. Levine;L. Cook;J. Grantham
分析了44例常染色体显性多囊肾病患者的肝脏CT表现，并与肝肾功能检查和肝脏、脾脏和肾脏CT体积测量结果进行了相关性分析。CT显示31.8%的患者有多个大的肝囊肿，25%的患者有小的肝囊肿，43.2%的患者无肝囊肿。有许多大囊肿的患者通常表现为肝脏体积增加。脾脏体积在有无肝囊肿的患者中无显著差异，提示门静脉高压症很少与囊性肝病相关。根据尿素氮、肌酐水平和肾脏体积，肝脏受累的严重程度与肾囊肿的程度之间没有相关性。除两名患者外，肝功能检查均正常，其中一名患者患有胆管癌，可能由囊肿引起，另一名患者患有感染性肝囊肿和慢性活动性肝炎。因此，如果肝功能检查异常，应尝试确定多囊肝病的并发症，如肿瘤，囊肿感染和胆道梗阻。这种并发症很少见，但在通过透析和肾移植延长生命的患者中可能会看到。CT是检测肝囊肿和识别有这些并发症风险的患者的有用方法。
Hepatic CT findings were analyzed in 44 patients with autosomal-dominant polycystic kidney disease and were correlated with liver and renal function tests and liver, splenic, and renal CT volume measurements. CT showed many large liver cysts in 31.8% of patients, small liver cysts in 25%, and no liver cysts in 43.2%. Patients with many large cysts often showed increased liver volumes. Splenic volumes did not differ significantly in patients with and without liver cysts, suggesting that portal hypertension is rarely associated with cystic liver disease. There was no correlation between severity of liver involvement and extent of renal cystic disease as determined from urea nitrogen and creatinine levels and renal volumes. Liver function tests were normal except in two patients, one with a cholangiocarcinoma, which may have arisen from a cyst, and the other with an infected liver cyst and chronic active hepatitis. Accordingly, if liver function tests are abnormal, an attempt should be made to identify complications of polycystic liver disease such as tumor, cyst infection, and biliary obstruction. Such complications are rare but may be seen in patients whose lives are prolonged by dialysis and renal transplantation. CT is a useful method for detecting liver cysts and identifying patients at risk for these complications.