SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease.
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease.
复制标题
SARM 1参与朊病毒病的轴突变性和线粒体功能障碍。
DOI：
10.4103/1673-5374.337051
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发表时间：
2022-10
影响因子：
6.1
通讯作者：
Yang, Li-Feng
中科院分区：
文献类型：
--
作者：
Lai, Meng-Yu;Li, Jie;Zhang, Xi-Xi;Wu, Wei;Li, Zhi-Ping;Sun, Zhi-Xin;Zhao, Meng-Yang;Yang, Dong-Ming;Wang, Dong-Dong;Li, Wen;Zhao, De-Ming;Zhou, Xiang-Mei;Yang, Li-Feng
关键词：
Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss, axonal degeneration, and mitochondrial dysfunction. Axonal degeneration is an early hallmark of neurodegeneration and is triggered by SARM1. We found that depletion or dysfunctional mutation of SARM1 protected against NAD+ loss, axonal degeneration, and mitochondrial functional disorder induced by the neurotoxic peptide PrP106–126. NAD+ supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective effect. NAD+ supplementation in PrP106–126-incubated N2a cells, SARM1 depletion, and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell survival. Our results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP106–126 are partially dependent on SARM1 NADase activity. This pathway has potential as a therapeutic target in the early stages of prion disease.
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影响因子：
6.1
作者：
Ishikawa T
通讯作者：
Ishikawa T
影响因子：
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