Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals
Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals
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DOI：
10.1034/j.1399-3003.2000.16d07.x
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发表时间：
2000-10-01
影响因子：
24.3
通讯作者：
Buhl, R
中科院分区：
文献类型：
--
作者：
Beeh, KM;Ksoll, M;Buhl, R
血清免疫球蛋白（IG）E升高是特应性的标志，并有助于特应性个体的哮喘和支气管高反应性。相反，IgE在非过敏性受试者中的意义不太清楚。本研究的目的是在没有临床过敏的情况下阐明IgE与哮喘的潜在联系，为此目的，对1,219例肺科实践的连续患者进行了评价。非过敏性患者通过皮肤点刺试验阴性、特应性病史和特异性IgE来定义，509例受试者（42%）是非过敏性的。其中，80例患者（16%）总IGE水平升高（>150 U.mL（-1））。将IgE>150 U.mL（-1）的非过敏性受试者与IgE正常的受试者的哮喘患病率和严重程度进行比较，并将所有非过敏性受试者和哮喘患者的肺功能参数与血清IgE相关。IgE水平升高的非过敏性受试者的哮喘患病率高于IgE正常的非过敏性受试者（39%对14%; P < 0.05）。
Elevated serum immunoglobulin (Ig)E is the hallmark of atopy, and contributes to asthma and bronchial hyperresponsiveness in atopic individuals. In contrast, the significance of IgE in nonallergic subjects is less clear. The aim of the present study is to clarify a potential association of IgE and asthma in absence of clinical allergy.To this purpose 1,219 consecutive patients of a pulmonary practice were evaluated. Nonallergic patients were defined by negative skin prick test, history of atopy and specific IgE, 509 subjects (42%) were nonallergic. Among these, 80 patients (16%) had elevated total IGE levels (>150 U.mL(-1)). Prevalence and severity of asthma in nonallergic subjects wit IgE>150 U.mL(-1) were compared with subjects with normal IgE levels, and lung function parameters were correlated with serum IgE in all nonallergic subjects and asthmatics.Asthma was more prevalent in nonallergic subjects with elevated IgE levels than in nonallergic subjects with normal IgE (39% versus 14%; p