The hormonal profile of benign breast disease.
The hormonal profile of benign breast disease.
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良性乳腺疾病的激素特征。
DOI：
10.1038/bjc.2012.493
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发表时间：
2013
影响因子：
8.8
通讯作者：
Lagiou,P
中科院分区：
文献类型：
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作者：
Samoli,E;Trichopoulos,D;Lagiou,A;Zourna,P;Georgila,C;Minaki,P;Barbouni,A;Vassilarou,D;Tsikkinis,A;Sfikas,C;Spanos,E;Lagiou,P
背景：关于乳腺良性疾病（BBD）的内分泌环境的信息有限，BBD是一种有文献记载的乳腺癌危险因素。我们比较了不同组织学类型的BBD患者和无乳腺病理的女性血液中雌激素、睾酮和胰岛素样生长因子-1 （IGF-1）的水平。方法：我们研究了希腊雅典的578名BBD患者和178名健康女性，他们提供了血液样本，并完成了访谈者管理的问卷。结果：非增生性病变254例，增生性病变268例，非典型增生56例。将BBD患者与健康女性进行比较，绝经前和围绝经期/绝经后女性血液激素的百分比差异（和95%置信区间）分别为：雌二醇的百分比差异为22.4%（- 4.0%,56.1%）和32.0%(5.6%,65.1%)；26.2%(10.1%, 44.8%)和30.9%(16.8%、46.6%)对雌激素酮;19.5%(3.1%, 38.4%)和16.5%(−5.0%、42.9%)对睾丸激素;和(−13.8%、4.4%)和−−5.2% 12.1%为igf - 1(−19.8%,−3.6%)。与非增殖性BBD相比，增殖性BBD的类固醇激素水平更高。结论：BBD女性的循环类固醇激素水平高于无乳腺病理的女性，而增生性疾病的循环类固醇激素水平高于非增生性疾病；这些模式在围绝经期/绝经后妇女中更为明显。在围绝经期/绝经后的女性中，与健康女性相比，患有BBD的女性的IGF-1较低。
Background:Limited information exists about the endocrine milieu of benign breast disease (BBD), a documented breast cancer risk factor. We compared blood levels of estrogens, testosterone and insulin-like growth factor-1 (IGF-1) between BBD patients by histological type and women without breast pathology.Methods:We studied 578 BBD patients and 178 healthy women in Athens, Greece, who provided blood samples, and completed interviewer-administered questionnaires.Results:Of the BBD patients, 254 had non-proliferative disease, 268 proliferative disease without atypia and 56 atypical hyperplasia. Comparing BBD patients with healthy women, the per cent differences (and 95% confidence intervals) for blood hormones, among pre-menopausal and peri/post-menopausal women, respectively, were: 22.4%(− 4.0%, 56.1%) and 32.0%(5.6%, 65.1%) for estradiol; 26.2%(10.1%, 44.8%) and 30.9%(16.8%, 46.6%) for estrone; 19.5%(3.1%, 38.4%) and 16.5%(− 5.0%, 42.9%) for testosterone; and− 5.2%(− 13.8%, 4.4%) and− 12.1%(− 19.8%,− 3.6%) for IGF-1. Steroid hormones tended to be higher in proliferative compared with non-proliferative BBD.Conclusions:Circulating steroid hormones tend to be higher among women with BBD than women with no breast pathology and higher in proliferative than non-proliferative disease; these patterns are more evident among peri/post-menopausal women. In peri/post-menopausal women IGF-1 was lower among women with BBD compared with healthy women.