Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).
Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA).
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DOI：
10.1186/s40478-018-0511-7
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发表时间：
2018-03-05
影响因子：
7.1
通讯作者：
Baier M
中科院分区：
文献类型：
--
作者：
Burwinkel M;Lutzenberger M;Heppner FL;Schulz-Schaeffer W;Baier M
β-淀粉样蛋白(A-β)的种子和扩散病理一直被认为是基于类病毒的机制。然而，Aβ种子活性在外周暴露时的有限传播性不仅在发病机制方面，而且在疾病的潜在传播方面，将代表着对普恩病毒的关键区别。在APP/β小鼠脑内注射不同脑匀浆后，我们对种子A-PS1淀粉样变性进行了部分表征。选择一种特别富含种子的匀浆来研究静脉暴露后Aβ的病理发展。我们在这里报告了一次静脉注射阿尔茨海默病患者的脑提取液到APP/PS1受体小鼠体内，在注射后180天内导致脑淀粉样血管病变。因此，血管蛋白病变，如CAA，可通过静脉途径外周暴露在小鼠身上传播。
Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent a key difference to prions, not only in terms of pathogenesis but also in terms of potential transmission of disease. We partially characterized the seeded Aβ amyloidosis after intracerebral injection of various brain homogenates in APP/PS1 mice. One particularly seed-laden homogenate was selected to investigate the development of Aβ pathologies after intravenous exposure. We report here that a single intravenous injection of an Alzheimer disease patient’s-brain extract into APP/PS1 recipient mice led to cerebral amyloid angiopathy within 180 days post injection. Thus, vascular proteinopathies such as CAA are transmissible in mice via the intravenous route of peripheral exposure.
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影响因子：
12.7
作者：
Ritchie DL;Adlard P;Peden AH;Lowrie S;Le Grice M;Burns K;Jackson RJ;Yull H;Keogh MJ;Wei W;Chinnery PF;Head MW;Ironside JW
通讯作者：
Ironside JW
影响因子：
64.8
作者：
Qiang W;Yau WM;Lu JX;Collinge J;Tycko R
通讯作者：
Tycko R
影响因子：
56.9
作者：
Meyer-Luehmann, Melanie;Coomaraswamy, Janaky;Jucker, Mathias
通讯作者：
Jucker, Mathias
影响因子：
4.6
作者：
Morales R;Bravo-Alegria J;Duran-Aniotz C;Soto C
通讯作者：
Soto C
影响因子：
4
作者：
Aslund, Andreas;Sigurdson, Christina J.;Klingstedt, Therese;Grathwohl, Stefan;Bolmont, Tristan;Dickstein, Dara L.;Glimsdal, Eirik;Prokop, Stefan;Lindgren, Mikael;Konradsson, Peter;Holtzman, David M.;Hof, Patrick R.;Heppner, Frank L.;Gandy, Samuel;Jucker, Mathias;Aguzzi, Adriano;Hammarstrom, Per;Nilsson, K. Peter R.
通讯作者：
Nilsson, K. Peter R.