A conserved malaria parasite protein required for maintenance of sporozoite cell shape and transmission.
A conserved malaria parasite protein required for maintenance of sporozoite cell shape and transmission.
复制标题
维持子孢子细胞形状和传播所需的保守疟疾寄生虫蛋白。
DOI：
10.1111/mmi.14910
复制
发表时间：
2022
影响因子：
3.6
通讯作者：
Dessens JT
中科院分区：
文献类型：
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作者：
Dessens JT
疟疾寄生虫由蚊子传播，寄生虫复杂生命周期的很大一部分发生在昆虫体内。寄生虫的传播始于用雌性媒介蚊子的血液从脊椎动物宿主中摄取称为配子体的寄生虫阶段，几周后通过蚊子叮咬将称为孢子子的寄生虫阶段注射到脊椎动物宿主中。数千个孢子子在蚊子中肠上皮腔侧的卵母细胞衍生卵囊内形成，这一过程被称为孢子形成。孢子形成后，从卵囊进入血淋巴，侵入唾液腺，成熟后感染脊椎动物。这篇微评论综述了最近关于伯氏疟原虫（plasmodium berghei）的一个保守质膜相关蛋白PBANKA_1422900的报道，以及它在维持唾液腺孢子体形状和结构完整性以及在脊椎动物宿主接种过程中的作用。三个独立研究的综合结果提供了这种蛋白质如何实现孢子体结构维护的机制见解，以及反过来如何促进孢子体克服几个物理障碍并允许其在脊椎动物中建立感染的能力。
Malaria parasites are transmitted by mosquitoes and a substantial part of the parasite's complex life cycle takes place inside the insect. Parasite transmission starts with the uptake of parasite stages called gametocytes from the vertebrate host with the blood meal of a female vector mosquito, completing several weeks later with the injection of parasite stages called sporozoites into the vertebrate host by mosquito bite. The sporozoites form in their thousands inside ookinete‐derived oocysts situated on the abluminal side of the mosquito midgut epithelium by a process of cell division known as sporogony. After their formation, sporozoites egress from the oocyst into the haemolymph, invade the salivary glands and mature to become infective to the vertebrate. This MicroCommentary reviews recent reports describing a conserved plasma membrane‐associated protein ofPlasmodium berghei, PBANKA_1422900, and its role in maintaining the shape and structural integrity of sporozoites in salivary glands and during inoculation into the vertebrate host. Combined results from three separate studies provide mechanistic insights into how this protein achieves structural maintenance of the sporozoite, and how in turn this promotes the sporozoite's ability to overcome several physical obstacles and allow it to establish infection in the vertebrate.