Innate immune signaling in the pathogenesis of necrotizing enterocolitis.
Innate immune signaling in the pathogenesis of necrotizing enterocolitis.
复制标题
线虫性小肠结肠炎发病机理中的先天免疫信号传导。
DOI：
10.1155/2013/475415
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发表时间：
2013
影响因子：
--
通讯作者：
Sodhi CP
中科院分区：
文献类型：
--
作者：
Hackam DJ;Afrazi A;Good M;Sodhi CP
坏死性小肠结肠炎（NEC）是一种具有挑战性的疾病，治疗和照顾患者仍然是令人沮丧和困难。虽然NEC可能发展迅速，没有警告，但它也可能发展缓慢，阴险，似乎让护理人员感到惊讶。在寻求理解导致NEC发展的分子和细胞过程中，我们已经确定了细菌脂多糖（LPS）Toll样受体4（TLR4）在NEC发病机制中的关键作用，因为其在早产儿肠上皮内的活化导致粘膜损伤和上皮修复减少。TLR4的表达和功能被发现是特别升高的肠粘膜内的早产儿相比，足月婴儿，诱发NEC的发展。重要的是，肠上皮细胞本身（如热休克蛋白70（Hsp70））和细胞外环境（如羊水）中的因素可以减少TLR4信号传导的程度，并降低NEC发展的倾向。这篇综述将强调导致NEC发展的关键TLR4介导的步骤，重点关注TLR4信号传导的促炎反应，这些反应在早产儿宿主中具有破坏性后果。
Necrotizing enterocolitis (NEC) is a challenging disease to treat, and caring for patients afflicted by it remains both frustrating and difficult. While NEC may develop quickly and without warning, it may also develop slowly, insidiously, and appear to take the caregiver by surprise. In seeking to understand the molecular and cellular processes that lead to NEC development, we have identified a critical role for the receptor for bacterial lipopolysaccharide (LPS) toll like receptor 4 (TLR4) in the pathogenesis of NEC, as its activation within the intestinal epithelium of the premature infant leads to mucosal injury and reduced epithelial repair. The expression and function of TLR4 were found to be particularly elevated within the intestinal mucosa of the premature as compared with the full-term infant, predisposing to NEC development. Importantly, factors within both the enterocyte itself, such as heat shock protein 70 (Hsp70), and in the extracellular environment, such as amniotic fluid, can curtail the extent of TLR4 signaling and reduce the propensity for NEC development. This review will highlight the critical TLR4-mediated steps that lead to NEC development, with a focus on the proinflammatory responses of TLR4 signaling that have such devastating consequences in the premature host.
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DOI：
10.4049/jimmunol.1103114
发表时间：
2012-05-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Afrazi A;Sodhi CP;Good M;Jia H;Siggers R;Yazji I;Ma C;Neal MD;Prindle T;Grant ZS;Branca MF;Ozolek J;Chang EB;Hackam DJ
通讯作者：
Hackam DJ
影响因子：
3.6
作者：
Afrazi A;Sodhi CP;Richardson W;Neal M;Good M;Siggers R;Hackam DJ
通讯作者：
Hackam DJ
DOI：
10.1152/ajpgi.00328.2004
发表时间：
2005-05-01
影响因子：
4.5
作者：
Fukata, M;Michelsen, KS;Abreu, MT
通讯作者：
Abreu, MT
DOI：
10.1152/ajpgi.00248.2012
发表时间：
2012-09-01
影响因子：
4.5
作者：
Coursodon-Boyiddle, Christine F.;Snarrenberg, Chelsea L.;Dvorak, Bohuslav
通讯作者：
Dvorak, Bohuslav
DOI：
10.1152/ajpgi.00317.2012
发表时间：
2013-01-01
影响因子：
4.5
作者：
Cherrington, Nathan J.;Estrada, Teresa E.;Halpern, Melissa D.
通讯作者：
Halpern, Melissa D.