Nonlinear pharmacokinetics of ethanol: the disproportionate AUC-dose relationship.
Nonlinear pharmacokinetics of ethanol: the disproportionate AUC-dose relationship.
复制标题
乙醇的非线性药代动力学：不成比例的 AUC-剂量关系。
DOI：
10.1111/j.1530-0277.1980.tb04836.x
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
L. O. Wilkin
中科院分区：
文献类型：
--
作者：
P. Wilkinson;G. Reynolds;O. D. Holmes;S. Yang;L. O. Wilkin
在等速静脉输注乙醇后，测量了4只比格犬的全静脉血乙醇浓度。五种不同剂量（0.1-0.8 g乙醇/kg体重）按规定的时间间隔给药。血乙醇浓度-时间曲线下面积与给药剂量呈明显的非线性关系。给出了具有Michaelis-Menten消除动力学和零阶输入的一室和二室开放模型的模拟，并给出了它们的auc -剂量理论关系。
Whole venous blood concentrations of ethyl alcohol were measured following the constant rate intravenous infusion of ethanol to four Beagle dogs. Five different doses (0.1-0.8 g ethanol/kg body weight) were administered at scheduled intervals. The area under the blood ethanol concentration-time curves (AUC) was found to demonstrate a markedly nonlinear relationship with the administered dose. Simulations of one and two compartment open models with Michaelis-Menten elimination kinetics and zero-order input are presented with their theoretical AUC-dose relationships.