Nutrition During Pregnancy Impacts Offspring's Epigenetic Status-Evidence from Human and Animal Studies.
Nutrition During Pregnancy Impacts Offspring's Epigenetic Status-Evidence from Human and Animal Studies.
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DOI：
10.4137/nmi.s29527
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发表时间：
2015
影响因子：
1.7
通讯作者：
Gibney ER
中科院分区：
文献类型：
--
作者：
Geraghty AA;Lindsay KL;Alberdi G;McAuliffe FM;Gibney ER
怀孕是生长发育的关键时期，在此期间，母亲的营养状况对母亲和婴儿未来的健康有着重大影响。在怀孕期间，胎儿经历了一个关键的可塑性时期。表观遗传学，特别是DNA甲基化，在这里起着重要的作用。由于营养对DNA甲基化有影响，本文旨在确定母亲在怀孕期间的营养是否可以改变后代出生时的表观基因组。研究重点是微量营养素和甲基供体，如叶酸和B族维生素。有证据表明，母体营养不会在很大程度上影响全球甲基化模式，特别是在营养充足的人群中;然而，观察到对基因特异性甲基化的重要影响。母亲的营养和后代的甲基化之间存在联系;然而，仍然缺乏研究。由于有可能使用出生时的DNA甲基化模式来预测孩子以后的健康状况，因此进行进一步的研究至关重要。
Pregnancy is a vital time of growth and development during which maternal nutrition significantly influences the future health of both mother and baby. During pregnancy, the fetus experiences a critical period of plasticity. Epigenetics, specifically DNA methylation, plays an important role here. As nutrition is influential for DNA methylation, this review aims to determine if maternal nutrition during pregnancy can modify the offspring’s epigenome at birth. Research focuses on micronutrients and methyl donors such as folate and B vitamins. Evidence suggests that maternal nutrition does not largely influence global methylation patterns, particularly in nutrient-replete populations; however, an important impact on gene-specific methylation is observed. A link is shown between maternal nutrition and the methylome of the offspring; however, there remains a paucity of research. With the potential to use DNA methylation patterns at birth to predict health of the child in later life, it is vital that further research be carried out.