Polymerization of a Photocleavable Monomer Using Visible Light
Polymerization of a Photocleavable Monomer Using Visible Light
复制标题
DOI：
10.1002/marc.201600127
复制
发表时间：
2016-06-01
影响因子：
4.6
通讯作者：
Lim, May
中科院分区：
文献类型：
--
作者：
Bagheri, Ali;Yeow, Jonathan;Lim, May
采用光诱导电子/能量转移可逆加成-断裂链转移聚合方法研究了光裂解单体甲基丙烯酸邻硝基苄酯（NBMA）的聚合。在可见红光（λ（max）= 635 nm，0.7 mW cm（-2））和黄光（λ（max）= 560 nm，9.7 mW cm（-2））下进行聚合，并证明了受控/活性自由基聚合方法的合理证据。定义明确的聚（邻硝基苄基甲基丙烯酸酯）（PNBMA）均聚物的分子量和聚合物的分散性具有良好的控制成功地合成通过改变照射时间和/或目标聚合度。用NBMA对聚（低聚乙二醇甲基醚甲基丙烯酸酯）大分子链转移剂进行扩链，制备了可光裂解的两亲性嵌段共聚物（BCP）。最后，这些自组装BCP在紫外光下迅速分解，表明NBMA的光响应特性在黄光或红光下的聚合过程中没有改变。这种光响应聚合物可潜在地用于治疗化合物的远程控制递送。
The polymerization of the photocleavable monomer, o-nitrobenzyl methacrylate (NBMA), is investigated using photoinduced electron/energy transfer reversible addition-fragmentation chain transfer polymerization. The polymerizations under visible red (lambda(max) = 635 nm, 0.7 mW cm(-2)) and yellow (lambda(max) = 560 nm, 9.7 mW cm(-2)) light are performed and demonstrate rational evidence of a controlled/living radical polymerization process. Well-defined poly(o-nitrobenzyl methacrylate) (PNBMA) homopolymers with good control over the molecular weight and polymer dispersity are successfully synthesized by varying the irradiation time and/or targeted degree of polymerization. Chain extension of a poly(oligo(ethylene glycol) methyl ether methacrylate) macro-chain transfer agent with NBMA is carried out to fabricate photocleavable amphiphilic block copolymers (BCP). Finally, these self-assembled BCP rapidly dissemble under UV light suggesting the photoresponsive character of NBMA is not altered during the polymerization under yellow or red light. Such photoresponsive polymers can be potentially used for the remote-controlled delivery of therapeutic compounds.