Cathepsin B and human tumor progression.
Cathepsin B and human tumor progression.
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DOI：
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发表时间：
1998-02
影响因子：
3.7
通讯作者：
S. Yan;M. Sameni;Bonnie F. Sloane
中科院分区：
文献类型：
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作者：
S. Yan;M. Sameni;Bonnie F. Sloane
组织蛋白酶 B 与多种人类肿瘤的进展有关。在不同的人类癌症中发现组织蛋白酶 B mRNA 过度表达、组织蛋白酶 B 染色增加和组织蛋白酶 B 活性升高。这些尤其发生在癌症的侵袭边缘，表明组织蛋白酶 B 在肿瘤侵袭中发挥作用。在某些肿瘤中，组织蛋白酶 B 的 mRNA 表达和蛋白质染色与临床进展相关。组织蛋白酶 B 可以通过降解基底膜和细胞外基质的成分直接促进肿瘤进展。体外研究表明，组织蛋白酶 B 可能在细胞内或细胞外发挥其降解作用，具体取决于细胞类型和组织蛋白酶 B 的位置。组织蛋白酶 B 还可以通过激活其他潜在蛋白酶和/或降解其他蛋白酶的蛋白质抑制剂来间接促进肿瘤进展。因此，组织蛋白酶 B 可能是与人类肿瘤恶性进展相关的蛋白水解级联的一个组成部分。
Cathepsin B has been implicated in progression of various human tumors. Overexpression of cathepsin B mRNA, increased cathepsin B staining and elevated cathepsin B activity have been found in different human cancers. These occur especially at the invasive edges of cancers, suggesting a role for cathepsin B in tumor invasion. In some tumors, mRNA expression and protein staining for cathepsin B correlate with clinical progression. Cathepsin B can facilitate tumor progression directly through degradation of components of the basement membrane and extracellular matrix. In vitro studies show that cathepsin B may exert its degradative effects intracellularly or extracellularly, depending on the cell type and location of cathepsin B. Cathepsin B can also facilitate tumor progression indirectly through activation of other latent proteases and/or degradation of protein inhibitors of other proteases. Thus cathepsin B may be an integral component of the proteolytic cascade linked to malignant progression of human tumors.