Interleukin 24: Signal Transduction Pathways.
Interleukin 24: Signal Transduction Pathways.
复制标题
白介素24：信号转导途径。
作者：
白细胞介素24是一种多效性免疫调节细胞因子。大量研究表明，在不同病理的动物模型和临床试验中，增强或抑制白细胞介素24的表达具有有益的作用。我们和其他人已经证明了白细胞介素24作为抗癌疗法、自身免疫性疾病和炎症的治疗效用。成功的药物靶向需要对下游信号通路有更深入的了解。在这篇综述中，我们讨论了白介素24触发的信号通路。白介素24是IL-10家族的一员，在抗肿瘤、伤口愈合反应、宿主防御、免疫调节和炎症中起着至关重要的作用。白细胞介素24由免疫细胞和非免疫细胞共同产生。其典型途径依赖于与质膜上特异性白细胞介素20受体的识别和相互作用，以及随后的细胞质Janus蛋白酪氨酸激酶(JAK)/信号换能器和转录激活因子（STAT）激活。IL-24下游非典型JAK/ stat独立信号通路的鉴定依赖于IL-24与细胞质中蛋白激酶R、线粒体内膜呼吸链蛋白以及内质网中Sigma 1受体等伴侣的相互作用。大量研究表明，在动物模型和不同病理的临床试验中，增强或抑制白细胞介素24的表达具有治疗作用。成功的药物靶向需要对下游信号通路有更深入的了解。在这篇综述中，我们讨论了IL-24触发的信号通路。
Interleukin 24 is a pleiotropic immunomodulatory cytokine. Numerous studies have shown that enhancing or inhibiting the expression of Interleukin 24 has a beneficial effect in animal models and clinical trials in different pathologies. We and others have already demonstrated the therapeutic utility of Interleukin 24 as an anticancer therapy and in autoimmune diseases and inflammation. Successful drug targeting will require a deeper understanding of the downstream signaling pathways. In this review, we discuss the signaling pathway triggered by Interleukin 24. Interleukin 24 is a member of the IL-10 family with crucial roles in antitumor, wound healing responses, host defense, immune regulation, and inflammation. Interleukin 24 is produced by both immune and nonimmune cells. Its canonical pathway relies on recognition and interaction with specific Interleukin 20 receptors in the plasma membrane and subsequent cytoplasmic Janus protein tyrosine kinases (JAK)/signal transducer and activator of the transcription (STAT) activation. The identification of noncanonical JAK/STAT-independent signaling pathways downstream of IL-24 relies on the interaction of IL-24 with protein kinase R in the cytosol, respiratory chain proteins in the inner mitochondrial membrane, and chaperones such as Sigma 1 Receptor in the endoplasmic reticulum. Numerous studies have shown that enhancing or inhibiting the expression of Interleukin 24 has a therapeutic effect in animal models and clinical trials in different pathologies. Successful drug targeting will require a deeper understanding of the downstream signaling pathways. In this review, we discuss the signaling pathway triggered by IL-24.
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影响因子：
16.6
作者：
McNally BD;Ashley DF;Hänschke L;Daou HN;Watt NT;Murfitt SA;MacCannell ADV;Whitehead A;Bowen TS;Sanders FWB;Vacca M;Witte KK;Davies GR;Bauer R;Griffin JL;Roberts LD
通讯作者：
Roberts LD
影响因子：
9.3
作者：
Burmeister, Amanda R.;Johnson, M. Brittany;Marriott, Ian
通讯作者：
Marriott, Ian
影响因子：
64.5
作者：
Liu, Siqi;Hur, Yun Ha;Cai, Xin;Cong, Qian;Yang, Yihao;Xu, Chiwei;Bilate, Angelina M.;Gonzales, Kevin Andrew Uy;Parigi, S. Martina;Cowley, Christopher J.;Hurwitz, Brian;Luo, Ji-Dung;Tseng, Tiffany;Gur-Cohen, Shiri;Sribour, Megan;Omelchenko, Tatiana;Levorse, John;Pasolli, Hilda Amalia;Thompson, Craig B.;Mucida, Daniel;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
4.4
作者：
Andoh, Akira;Shioya, Makoto;Fujiyama, Yoshihide
通讯作者：
Fujiyama, Yoshihide
影响因子：
3.1
作者：
Lee, Ki-Mo;Kang, Haeng-A.;Kang, Hyung-Sik
通讯作者：
Kang, Hyung-Sik