Relationships of whole blood serotonin and plasma norepinephrine within families.
Relationships of whole blood serotonin and plasma norepinephrine within families.
复制标题
家庭内全血血清素和血浆去甲肾上腺素的关系。
DOI：
10.1007/bf02216055
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发表时间：
1990
影响因子：
3.9
通讯作者：
Freedman,DX
中科院分区：
文献类型：
--
作者：
Leventhal,BL;CookJr,EH;Morford,M;Ravitz,A;Freedman,DX
测定了47个孤独症先证者家系的全血5-羟色胺（5-HT）和血浆去甲肾上腺素（NE）水平，以研究这些指标在家系内的关系。自闭症儿童与其母亲、父亲和兄弟姐妹之间的全血5-HT（而非血浆NE）呈显著正相关。研究的47个家庭中有23个至少有1名高血压成员。在这23个家族中，10个（43.5%）有2名或2名以上高胆固醇血症成员;确定了5个家族，其中每个研究的家族成员都有高胆固醇血症（全血5 HT> 270 ng/ml）。如果一个家庭的自闭症儿童患有高血清素血症，那么一级亲属患高血清素血症的可能性是自闭症儿童不患有高血清素血症的2.4倍。平均全血5羟色胺水平高于自闭症患者的父母或兄弟姐妹。孤独症患者血浆NE水平低于孤独症先证者。这项研究重复了先前的研究，显示自闭症儿童家庭中高胆固醇血症的家族关系。
Whole blood serotonin (5HT) and plasma norepinephrine (NE) levels were determined in 47 families of autistic probands to study relationships within families of these measures. Whole blood 5HT, but not plasma NE, was significantly positively correlated between autistic children and their mothers, fathers, and siblings. Twenty-three of the 47 families studied had at least 1 hyperserotonemic member. Of these 23 families, 10 (43.5%) had 2 or more hyperserotonemic members; 5 families were identified in which each family member studied had hyperserotonemia (whole blood 5HT > 270 ng/ml). If the autistic child of a family was hyperserotonemic, the first-degree relatives were 2.4 times more likely to be hypersertonemic than if the autistic child was not hyperserotonemic. Mean whole blood 5HT levels were higher in autistic subjects than their parents or siblings. Siblings were found to have lower plasma NE than autistic probands. This study replicates a previous study showing familial relationships of hyperserotonemia within families with autistic children.