Rapid Production of Specialized Animal Handling Devices Using Computer-Aided Design and Solid Freeform Fabrication
Rapid Production of Specialized Animal Handling Devices Using Computer-Aided Design and Solid Freeform Fabrication
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DOI：
10.1002/jmri.21821
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发表时间：
2009-08-01
影响因子：
4.4
通讯作者：
Johnson, G. Allan
中科院分区：
文献类型：
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作者：
Howles, Gabriel P.;Nouls, John C.;Johnson, G. Allan
目的：为了开发一种用于快速和廉价地生产定制的动物处理装置的小动物imaging.Materials和方法：为了满足特定的成像实验的具体需要，测量从成像数据和动物处理装置的设计使用3D计算机辅助设计（CAD）软件。使用实体自由成型制造（SFF，a.k.a.快速成型）。结果：这一过程是说明与生产的动物处理系统的立体定向规定的治疗性超声和MRI的小鼠大脑。该器械在模块化系统中提供集成的头部固定、麻醉输送和生理监测。设计和生产大约需要1周的时间，成本是一个传统的机械shop.Conclusion的一小部分：商业动物处理产品通常具有有限的功能，并没有与其他实验室基础设施集成。然而，使用CAD和SFF，可以生产复杂的动物处理设备，以满足特定的实验需求。这个过程通常比使用传统的机器车间更快，更便宜，而且产品比典型的自制设备更坚固。使用高质量的专用设备可以以更高的一致性和更高的吞吐量执行实验。
Purpose: To develop a process for rapidly and inexpensively producing customized animal handling devices for small animal imaging.Materials and Methods: To meet the specific needs of a particular imaging experiment, measurements are taken from imaging data and the animal handling devices are designed using 3D computer-aided design (CAD) software. Parts are produced in a few days using solid freeform fabrication (SFF, a.k.a. rapid prototyping).Results: This process is illustrated with the production of an animal handling system for stereotaxically prescribed therapeutic ultrasound and MRI of the mouse brain. The device provides integrated head-fixation, anesthesia delivery, and physiological monitoring in a modular system. Design and production took approximate to 1 week and the cost was a small fraction of a traditional machine shop.Conclusion: Commercial animal handling products typically have limited functionality and are not integrated with other laboratory infrastructure. However, using CAD and SFF, sophisticated animal handling devices can be produced to meet the specific experimental needs. This process is typically faster and less expensive than using a traditional machine shop, and the products are more robust than typical homemade devices. Using high-quality purpose-built devices permits experiments to be executed with greater consistency and higher throughput.