Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer
Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer
复制标题
八聚体转录因子 1 通过上调己糖激酶 2 在非小细胞肺癌中诱导 Warburg 效应
DOI：
10.1007/s11010-021-04171-9
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发表时间：
2021-05-10
影响因子：
4.3
通讯作者：
Zhang, Shuai
中科院分区：
文献类型：
--
作者：
Li, Zhen;Su, Jin;Zhang, Shuai
能量代谢的重新编程是世界范围内流行的癌症的一个标志。八聚体转录因子-1(OCT1)是一种广为人知的转录因子。然而，OCT1在代谢重塑中的作用尚不清楚。在目前的研究中，我们发现OCT1在非小细胞肺癌(NSCLC)中上调，并与患者较差的生存相关。进一步的数据证实，OCT1增加了糖酵解通量，促进了肺癌细胞的增殖。在机制上，OCT1通过上调Warburg效应的关键酶己糖激酶2(HK2)促进有氧糖酵解和细胞增殖。因此，我们的研究结果表明，在非小细胞肺癌中，高水平的OCT1通过上调HK2而参与Warburg效应，将OCT1/HK2轴与肿瘤进展联系起来，这为NSCLC的治疗提供了潜在的生物标志物和治疗靶点。
Reprogramming of energy metabolism is a hallmark of cancer which is prevalent worldwide. Octamer transcription factor-1 (OCT1) is a well-known transcription factor. However, the role of OCT1 in metabolism remodeling has not been well defined. In the present study, we found that OCT1 was up-regulated in non-small cell lung cancer (NSCLC) and correlated with poor patient survival. Further data identified that OCT1 increased glycolysis flux, promoting proliferation in lung cancer cells. Mechanistically, OCT1 facilitated the aerobic glycolysis and cell proliferation via up-regulation of hexokinase 2 (HK2), a crucial enzyme of the Warburg effect. Hence, our findings indicate that, in NSCLC, high levels of OCT1 contribute to the Warburg effect through up-regulation of HK2, linking up the OCT1/HK2 axis and cancer progression, which provide a potential biomarker and therapeutic target for NSCLC treatment.