KINETICS OF SERUM AMYLOID PROTEIN-A IN CASEIN-INDUCED MURINE AMYLOIDOSIS
KINETICS OF SERUM AMYLOID PROTEIN-A IN CASEIN-INDUCED MURINE AMYLOIDOSIS
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DOI：
10.1172/jci108654
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发表时间：
1977-01-01
影响因子：
15.9
通讯作者：
SKINNER, M
中科院分区：
文献类型：
--
作者：
BENSON, MD;SCHEINBERG, MA;SKINNER, M
Serum amyloid protein A (SAA), the precursor of secondary amyloid protein, is elevated in chronic diseases which are associated with an increased incidence of amyloid. The murine model of casein-induced amyloidosis was studied to determine the relationship between SAA production and amyloid deposition. SAA levels measured by radioimmunoassay were as high as 200 times the normal level in CBA/J mice receiving daily parenteral casein. After a single injection of casein the SAA level was elevated by 3 h and peaked by 12-18 h. Similar levels were found in casein-treated A/J mice, a strain less susceptible to the induction of amyloid. Parenterally administered bovine serum albumin, which has low potential for amyloid induction, gave SAA levels in CBA/J and A/J mice comparable to casein treatment. While SAA levels are elevated during chronic antigenic stimulation, there are other factors involved in amyloid formation. These factors may include alterations in the degradation of SAA by the reticuloendothelial system caused by substances such as casein. Nude (athymic) mice attained high levels of SAA after receiving casein parenterally. Therefore, thymus-derived lymphocytes are not necessary for the synthesis of SAA.
