Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp
Measurement of insulin-mediated glucose uptake: Direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp
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DOI：
10.1016/j.metabol.2012.10.002
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发表时间：
2013-04-01
影响因子：
9.8
通讯作者：
Abbasi, Fahim
中科院分区：
文献类型：
--
作者：
Knowles, Joshua W.;Assimes, Themistocles L.;Abbasi, Fahim
背景。外周胰岛素敏感性的两种直接测量方法是由正血糖、高胰岛素钳夹（EC）得出的M值和由胰岛素抑制试验（IST）得出的稳态血浆葡萄糖（SSPG）浓度。先前的研究表明，这些测量是高度相关的，但它们之间的一致性是未知的。为了确定SSPG和M之间的一致性，并建立转换方程，将SSPG转换为M，反之亦然，我们直接比较了同一个体的这两种测量。共有15名非糖尿病受试者（9名女性和6名男性）在5天的中位间隔内接受了EC和改良版的IST。我们对这两个度量进行了标准的相关度量，并为这两个度量建立了转换回归方程。受试者的平均±SD年龄为57±7岁，体重指数为27.7±3.9 kg/m(2)。SSPG浓度中位数（四分位数间距）为6.7 (5.1,9.8)mmol/L， M值为49.6 (28.9,64.2)mu mol/min/kg-LBM。SSPG与M呈极显著相关(r=-0.87， P
Background. Two direct measurements of peripheral insulin sensitivity are the M value derived from the euglycemic, hyperinsulinemic clamp (EC) and the steady-state plasma glucose (SSPG) concentration derived from the insulin suppression test (IST). Prior work suggests that these measures are highly correlated, but the agreement between them is unknown. To determine the agreement between SSPG and M and to develop transformation equations to convert SSPG to M and vice versa, we directly compared these two measurements in the same individuals.Methods. A total of 15 nondiabetic subjects (9 women and 6 men) underwent both an EC and a modified version of the IST within a median interval of 5 days. We performed standard correlation metrics of the two measures and developed transformation regression equations for the two measures.Results. The mean +/- SD age of the subjects was 57 +/- 7 years and body mass index, 27.7 +/- 3.9 kg/m(2). The median (interquartile range) SSPG concentration was 6.7 (5.1, 9.8) mmol/L and M value, 49.6 (28.9, 64.2) mu mol/min/kg-LBM. There was a highly significant correlation between SSPG and M (r=-0.87, P