Dopamine transporter polymorphism associated with externalizing behavior problems in children.
Dopamine transporter polymorphism associated with externalizing behavior problems in children.
复制标题
DOI：
10.1002/ajmg.10155
复制
发表时间：
2002-03
期刊：
影响因子：
--
通讯作者：
S. Young;A. Smolen;R. Corley;K. Krauter;J. Defries;T. Crowley;J. Hewitt
中科院分区：
文献类型：
--
作者：
S. Young;A. Smolen;R. Corley;K. Krauter;J. Defries;T. Crowley;J. Hewitt
幼儿外化行为是一种稳定且可遗传的攻击性和犯罪行为模式，通常会导致严重的精神疾病，例如品行障碍和注意力缺陷多动障碍。我们在 790 名儿童的社区样本中检查了父母报告的外化行为（在 4、7 和 9 岁时评估）与 SLC6A3 (DAT1) 3' 非翻译区的 VNTR 多态性之间的关系，这是我们纵向双胞胎和收养研究的一部分。我们应用了 Fulker 等人开发的基于兄弟姐妹的方法。 [1999: Am J Hum Genet 64:259-267] 用于估计等位基因与数量性状的关联，同时控制群体分层。这些方法的扩展允许包括同卵双胞胎、异卵双胞胎、兄弟姐妹和单胎。我们已经证明，DAT1 的 9 次重复变异是 4 岁 (P=0.001) 和 7 岁 (P=0.02) 外化行为的显着风险等位基因。尽管在 9 岁时效应大小可以忽略不计 (P=0.92)，但对三个年龄段的发育效应下降的正式测试并不显着 (P=0.70)。
Early childhood externalizing behavior is a stable and heritable pattern of aggressive and delinquent behavior that often leads to the development of serious psychiatric disorders such as conduct disorder and attention deficit hyperactivity disorder. We examined the relationship between parent reported externalizing behavior (assessed at ages 4, 7, and 9 years) and the VNTR polymorphism of the 3' untranslated region of SLC6A3 (DAT1) in a community sample of 790 children ascertained as part of our longitudinal twin and adoption studies. We applied the sibling-based methodology developed by Fulker et al. [1999: Am J Hum Genet 64:259-267] for estimating allelic association with quantitative traits, while controlling for population stratification. An extension of these methods allowed for the inclusion of monozygotic twins, dizygotic twins, siblings, and singletons. We have demonstrated that the 9-repeat variant of the DAT1 is a significant risk allele for externalizing behavior at ages 4 (P=0.001) and 7 years (P=0.02). Although the effect size was negligible at age 9 (P=0.92), a formal test of the developmental decrease in effect across the three ages was non-significant (P=0.70).