Circulating tumor cells prior to initial treatment is an important prognostic factor of survival in non-small cell lung cancer: a meta-analysis and system review
Circulating tumor cells prior to initial treatment is an important prognostic factor of survival in non-small cell lung cancer: a meta-analysis and system review
复制标题
初始治疗前的循环肿瘤细胞是非小细胞肺癌生存的重要预后因素：荟萃分析和系统评价。
DOI：
10.1186/s12890-019-1029-x
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发表时间：
2019-12-26
影响因子：
3.1
通讯作者：
Wang, Ru-Wen
中科院分区：
文献类型：
--
作者：
Jiang, Sha-Sha;Deng, Bo;Wang, Ru-Wen
背景资料：我们的研究旨在通过对已发表的研究进行荟萃分析和系统回顾，验证初始治疗前循环肿瘤细胞（CTC）对非小细胞肺癌（NSCLC）生存的预后价值。材料和方法：分别检索PubMed、EMBASE和科克伦图书馆，确定所有在初始治疗前解决CTC问题以及无进展生存期（PFS）和总生存期（OS）的研究。最后，采用ReviewManager5.3统计软件和STATA15.0软件对10篇引文进行分析和评价。多变量考克斯比例风险回归分析的随机模型表明，CTC丰度越高，基于PFS和预后，肺癌病例的预后越差结论：初治前高CTC可预测NSCLC患者较短的PFS和OS，值得进一步研究。
Background: Our study aimed to verify the prognostic value of circulating tumor cells (CTCs) prior to initial treatment on survival of non-small cell lung cancer (NSCLC) by using meta-analysis and system review of published studies.Materials and methods: The PubMed, EMBASE and Cochrane Library were searched, respectively, to identify all studies that addressed the issues of CTCs prior to initial treatment and progression-free survival (PFS) and overall survival (OS). Finally, ten citations were included for analysis and assessment of publication bias by using review manager 5.3 statistical software and STATA 15.0.Results: Randomized model analyzing multivariate Cox Proportional Hazards Regression indicated that higher abundance of CTCs significantly predicts poorer prognosis of lung cancer cases basing both on PFS (Z = 2.31, P = 0.02) and OS of advanced cases (Z = 2.44, P = 0.01), and systematic study aslo indicated the similar results.Conclusion: High CTCs prior to initial treatment can predict shorter PFS and OS in NSCLC, and further studies are warranted in the future.