THE TEMPORAL-SPATIAL DYNAMICS OF FEATURE MAPS DURING MONOCULAR DEPRIVATION REVEALED BY CHRONIC IMAGING AND SELF-ORGANIZATION MODEL SIMULATION
THE TEMPORAL-SPATIAL DYNAMICS OF FEATURE MAPS DURING MONOCULAR DEPRIVATION REVEALED BY CHRONIC IMAGING AND SELF-ORGANIZATION MODEL SIMULATION
复制标题
慢性成像和自组织模型模拟揭示单目剥夺期间特征图的时空动力学
DOI：
10.1016/j.neuroscience.2016.10.014
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发表时间：
2016
期刊：
影响因子：
3.3
通讯作者：
Yu Hongbo
中科院分区：
文献类型：
--
作者：
Tong Lei;Xie Yang;Yu Hongbo
对猫、雪貂和猴子的成年视觉皮层的实验揭示了多个特征图之间的有组织的空间关系，这些特征图也可以由Kohonen和弹性网络自组织模型再现。然而，试图应用这些模型来模拟单眼剥夺（MD）在关键时期的时间动力学，以及它们对特征图的空间排列的影响，导致了相互矛盾的结果。在这项研究中，我们进行了MD和慢性成像在雪貂视觉皮层的关键时期的眼优势（OD）可塑性。我们还使用Kohonen模型来模拟MD对OD和方向图开发的影响。实验和模拟都证明了两个一般的参数不敏感的结果。具体来说，我们的第一个发现表明，OD指数的变化导致的MD，其随后的恢复在双眼视觉（BV），都是非线性的，与一个显着更强的转变发生在初始阶段。同时，空间重组的特征地图导致全球不变，但局部移动的地图模式。详细地说，我们发现，OD和方向图的周期性保持不变，期间和之后，剥夺。OD和方向图之间的关系保持相似，但由于OD边界的变化显着减弱。这些结果表明，地图之间的正交梯度关系可能是预先设定的，并且在关键时期仅可轻微修改。Kohonen模型能够再现这些实验结果，因此其作用进一步扩展到描述发育过程中的皮质特征图动态。
Experiments on the adult visual cortex of cats, ferrets and monkeys have revealed organized spatial relationships between multiple feature maps which can also be reproduced by the Kohonen and elastic net self-organization models. However, attempts to apply these models to simulate the temporal kinetics of monocular deprivation (MD) during the critical period, and their effects on the spatial arrangement of feature maps, have led to conflicting results. In this study, we performed MD and chronic imaging in the ferret visual cortex during the critical period of ocular dominance (OD) plasticity. We also used the Kohonen model to simulate the effects of MD on OD and orientation map development. Both the experiments and simulations demonstrated two general parameter-insensitive findings. Specifically, our first finding demonstrated that the OD index shift resulting from MD, and its subsequent recovery during binocular vision (BV), were both nonlinear, with a significantly stronger shift occurring during the initial period. Meanwhile, spatial reorganization of feature maps led to globally unchanged but locally shifted map patterns. In detail, we found that the periodicity of OD and orientation maps remained unchanged during, and after, deprivation. Relationships between OD and orientation maps remained similar but were significantly weakened due to OD border shifts. These results indicate that orthogonal gradient relationships between maps may be preset and are only mildly modifiable during the critical period. The Kohonen model was able to reproduce these experimental results, hence its role is further extended to the description of cortical feature map dynamics during development.