Amino acids, including neurotransmitter candidates, in a hair cell-enriched fraction from the lateral line of Xenopus laevis.
Amino acids, including neurotransmitter candidates, in a hair cell-enriched fraction from the lateral line of Xenopus laevis.
复制标题
来自非洲爪蟾侧线的毛细胞富集部分中的氨基酸，包括候选神经递质。
DOI：
10.1016/0300-9629(87)90540-8
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Drescher,DG
中科院分区：
文献类型：
--
作者：
Drescher,MJ;Drescher,DG
本文比较了非洲爪蟾侧线毛细胞富集的神经肥大部分与相邻触觉器官和表皮的含初级胺成分含量。用阳离子交换高效液相色谱法荧光检测邻苯二醛加合物的32种成分中，l - α -氨基己二酸、o-磷酸乙醇胺、l - α -甘油磷酸乙醇胺、o-磷酸-l -丝氨酸和l -赖氨酸在神经肥大中的浓度相对于触觉器官和/或表皮升高。l -天冬氨酸、l -天冬氨酸、l -谷氨酸和牛磺酸在触觉器官或表皮中的含量高于神经肥大。在神经肥大中只发现了微量的牛磺酸。触觉器官和表皮含有至少3种未知的伯胺成分，这些成分在神经肥大中不存在或数量减少。本研究表明，非洲爪蟾侧线表皮来源的含有毛细胞的神经肥大在分子组成上与周围表皮来源组织不同。这种差异可能反映了特殊的机械感受功能。
A hair cell-enriched neuromast fraction from the lateral line of Xenopus laevis was compared with adjacent tactile organ and epidermis for content of primary amine-containing components. Of 32 components quantitated by cation-exchange HPLC with fluorescence detection of orthophthalaldehyde adducts, L-alpha-amino adipic acid, O-phosphoethanolamine, L-alpha-glycerophosphorylethanolamine, O-phospho-L-serine, and L-lysine were elevated in concentration in the neuromast relative to the tactile organ an/or epidermis. L-Aspartic acid, L-asparagine, L-glutamic acid, and taurine were present at higher levels in the tactile organ or epidermis than in the neuromast. Taurine was found in only trace amounts in the neuromast. The tactile organ and epidermis contained at least 3 unidentified primary amine components that were absent or reduced in amount in the neuromast. This study demonstrates that the epidermally-derived, hair cell-containing neuromast of the lateral line of Xenopus laevis is different in molecular composition from surrounding epidermally-derived tissue. Such differences may reflect specialized mechanoreceptive function.