Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes.
Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes.
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DOI：
10.1289/ehp.1510185
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发表时间：
2016-06
影响因子：
10.4
通讯作者：
Christiani DC
中科院分区：
文献类型：
--
作者：
Allen JG;Flanigan SS;LeBlanc M;Vallarino J;MacNaughton P;Stewart JH;Christiani DC
目前市场上有超过7,000种电子烟口味。调味化学品在21世纪初获得了恶名，当时吸入暴露的调味化学品双乙酰被发现与一种被称为“爆米花肺”的疾病有关。关于电子烟中的调味化学品的研究有限。我们的目的是确定调味化学品双乙酰和其他两种高优先级的调味化学品，2，3-戊二酮和乙偶姻，是否存在于调味电子烟的便利样品中。我们选择了领先的电子烟品牌销售的51种口味的电子烟，以及我们认为对年轻人有吸引力的口味。将电子烟内容物完全排出，并捕获空气流，并根据OSHA方法1012分析二乙酰、2，3_戊二酮和乙偶姻的总质量。在测试的51种独特口味中，有47种至少检测到一种调味化学物质。在测试的51种口味中，有39种检测到双乙酰高于实验室检测限，范围从低于定量限到239 μg/电子烟。在测试的51种香料中，分别有23种和46种检测到2，3-戊二酮和乙偶姻，浓度分别高达64和529 μg/支电子烟。由于双乙酰和闭塞性细支气管炎以及在工人中观察到的其他严重呼吸道疾病之间的关联，建议采取紧急行动，进一步评估通过调味电子烟可能广泛的暴露。艾伦JG，弗拉尼根SS，LeBlanc M，Vallarino J，MacNaughton P，Stewart JH，Christiani DC. 2016.电子烟中的调味化学品：51种产品样本中的双乙酰，2，3-戊二酮和乙偶姻，包括水果，糖果和鸡尾酒口味的电子烟。环境健康展望124：733-739; http：dx.doi.org/10.1289/ehp.1510185
There are > 7,000 e-cigarette flavors currently marketed. Flavoring chemicals gained notoriety in the early 2000s when inhalation exposure of the flavoring chemical diacetyl was found to be associated with a disease that became known as “popcorn lung.” There has been limited research on flavoring chemicals in e-cigarettes. We aimed to determine if the flavoring chemical diacetyl and two other high-priority flavoring chemicals, 2,3-pentanedione and acetoin, are present in a convenience sample of flavored e-cigarettes. We selected 51 types of flavored e-cigarettes sold by leading e-cigarette brands and flavors we deemed were appealing to youth. E-cigarette contents were fully discharged and the air stream was captured and analyzed for total mass of diacetyl, 2,3-pentanedione, and acetoin, according to OSHA method 1012. At least one flavoring chemical was detected in 47 of 51 unique flavors tested. Diacetyl was detected above the laboratory limit of detection in 39 of the 51 flavors tested, ranging from below the limit of quantification to 239 μg/e-cigarette. 2,3-Pentanedione and acetoin were detected in 23 and 46 of the 51 flavors tested at concentrations up to 64 and 529 μg/e-cigarette, respectively. Because of the associations between diacetyl and bronchiolitis obliterans and other severe respiratory diseases observed in workers, urgent action is recommended to further evaluate this potentially widespread exposure via flavored e-cigarettes. Allen JG, Flanigan SS, LeBlanc M, Vallarino J, MacNaughton P, Stewart JH, Christiani DC. 2016. Flavoring chemicals in e-cigarettes: diacetyl, 2,3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored e-cigarettes. Environ Health Perspect 124:733–739; http://dx.doi.org/10.1289/ehp.1510185