Kaposi's Sarcoma Associated Herpesvirus Entry into Target Cells.
Kaposi's Sarcoma Associated Herpesvirus Entry into Target Cells.
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DOI：
10.3389/fmicb.2012.00006
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发表时间：
2012
影响因子：
5.2
通讯作者：
Chandran B
中科院分区：
文献类型：
--
作者：
Chakraborty S;Veettil MV;Chandran B
疱疹病毒感染靶细胞是一个涉及多种宿主细胞表面分子（受体）和多种病毒包膜糖蛋白的复杂过程。卡波西肉瘤相关疱疹病毒（KSHV或HHV-8）感染多种体内靶细胞，如内皮细胞、B细胞、单核细胞、上皮细胞和角化细胞。KSHV还感染多种体外靶细胞，并在许多这些细胞类型中建立体外潜伏期。KSHV与宿主细胞表面分子的相互作用及其进入各种靶细胞的方式是了解KSHV发病机制的关键。KSHV是第一个显示与粘附靶细胞整合素相互作用的疱疹病毒，这种相互作用启动宿主细胞先前存在的信号通路，用于成功感染。本章讨论了早期KSHV感染靶细胞的各个方面，使用的受体和需要澄清的问题，以及未来的发展方向。本文总结了KSHV感染引发的各种信号事件以及信号事件在感染不同阶段的潜在作用，为进一步深入研究KSHV的发病机制提供了框架和出发点。
Herpesvirus infection of target cells is a complex process involving multiple host cell surface molecules (receptors) and multiple viral envelope glycoproteins. Kaposi’s sarcoma associated herpesvirus (KSHV or HHV-8) infects a variety of in vivo target cells such as endothelial cells, B cells, monocytes, epithelial cells, and keratinocytes. KSHV also infects a diversity of in vitro target cells and establishes in vitro latency in many of these cell types. KSHV interactions with the host cell surface molecules and its mode of entry in the various target cells are critical for the understanding of KSHV pathogenesis. KSHV is the first herpesvirus shown to interact with adherent target cell integrins and this interaction initiates the host cell pre-existing signal pathways that are utilized for successful infection. This chapter discusses the various aspects of the early stage of KSHV infection of target cells, receptors used and issues that need to be clarified, and future directions. The various signaling events triggered by KSHV infection and the potential role of signaling events in the different stages of infection are summarized providing the framework and starting point for further detailed studies essential to fully comprehend the pathogenesis of KSHV.
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