Oviductal-derived growth factors and cytokines: Implication in preimplantation
Oviductal-derived growth factors and cytokines: Implication in preimplantation
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DOI：
10.1055/s-2007-1016332
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发表时间：
1996-08-01
期刊：
影响因子：
--
通讯作者：
Chegini, N
中科院分区：
文献类型：
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作者：
Chegini, N
除了作为受精发生的管道外，输卵管还负责许多被认为在调节受孕前和早期胚胎发育过程中重要的分泌产物。输卵管上皮层由纤毛和非纤毛(分泌)细胞组成，在月经周期中经历形态和分泌的改变。与子宫等其他对类固醇敏感的组织一样，这些变化在一定程度上受到卵巢类固醇循环水平变化的影响。1、2这些细胞在卵泡晚期和黄体早期达到最大高度，分泌细胞的高度变化比纤毛细胞大。萎缩和脱落发生在黄体期的晚期，随后在卵泡期早期肥大和消退。1、2输卵管上皮衬里的这些形态和生化变化对精子和卵子的运输是必不可少的，并与卵母细胞最终成熟、精子获能、受精和早期胚胎发育时期相吻合。1-3在植入前和植入后建立和维持可存活胚胎仍然是哺乳动物物种中最耐人寻味的生物学事件之一。在受精和发育到输卵管的桑拿期后，胚胎进入子宫，并进一步发育成囊胚。虽然卵巢类固醇在这一过程中的重要性已经得到很好的证实，但几乎没有证据支持输卵管衍生因子在植入前胚胎中发挥作用。
In addition to serving as a conduit in which fertilization occurs, the fallopian tubes are responsible for numerous secretory products thought to be important in regulating the events preceding conception and early embryonic development. The oviductal epithelial lining consists of ciliated and nonciliated (secretory) cells that undergo both morphologic and secretory alterations during the menstrual cycle. As with other steroid-sensitive tissues such as the uterus, these alterations are influenced in part by changes in the circulating level of the ovarian steroids. 1, 2 These cells reach their maximum height during the late follicular and early luteal phases, with secretory cells undergoing more height variation than ciliated cells. Atrophy and deciliation occur late in the luteal phase, followed by hypertrophy and reciliation during the early follicular phase. 1, 2 These morphologic and biochemical changes in the tubal epithelial lining are essential for the transport of sperm and the egg, and coincide with the period of final oocyte maturation, sperm capacitation, fertilization, and early embryonic development. 1-3The establishment and maintenance of a viable embryo during preimplantation and postimplantation remains one of the most intriguing biological events in mammalian species. After fertilization and development into the morula stage in the oviduct the embryo moves into the uterus and further develops into a blastocyst. While the importance of ovarian steroids in this process has been well established, there is little evidence to support that oviductal-derived factors play a role in preimplantation embry-