Nucleosomal distribution of thymine photodimers following far- and near-ultraviolet irradiation.
Nucleosomal distribution of thymine photodimers following far- and near-ultraviolet irradiation.
复制标题
远紫外线和近紫外线照射后胸腺嘧啶光二聚体的核小体分布。
DOI：
10.1016/0006-291x(82)91098-1
复制
发表时间：
1982
影响因子：
3.1
通讯作者：
P. Cerutti
中科院分区：
文献类型：
--
作者：
H. Niggli;P. Cerutti
用低剂量的254 nm远紫外光和313 nm近紫外光照射正常人皮肤成纤维细胞后，测定顺式-顺式环丁基型胸腺嘧啶光二聚体的核小体分布。胸腺嘧啶光二聚体的浓度测定的总细胞DNA和核小体核心和chromosomal-DNA的酸水解产物中的高压液相色谱法。从这些数据计算接头-DNA中的损伤浓度。而胸腺嘧啶光二聚体分布均匀，254 nm照射后，他们的核小体接头DNA中富集的2.4 - 4.2倍，暴露于313 nm的光。
The nucleosomal distribution of cis-syn cyclobutyl-type thymine photodimers was determined in normal human skin fibroblasts following irradiation with low doses of far-ultraviolet light at 254 nm and nearultraviolet light at 313 nm. The thymine photodimer concentrations were determined by high pressure liquid chromatography in acid hydrolysates of total cellular DNA and of nucleosomal core- and chromatosomal-DNA. The lesion concentrations in linker-DNA were calculated from these data. While thymine photodimers were distributed uniformely following 254 nm irradiation they were enriched by a factor of 2.4 – 4.2 in nucleosomal linker DNA after exposure to 313 nm light.
灵敏测定紫外线照射的哺乳动物细胞 DNA 中的嘧啶二聚体。
DOI：
10.1016/0027-5107(81)90148-2
发表时间：
1981
期刊：
Mutation research
影响因子：
--
作者：
vanZeeland,AA;Smith,CA;Hanawalt,PC
通讯作者：
Hanawalt,PC