MONOCLONAL-ANTIBODY TO FIBRONECTIN WHICH INHIBITS EXTRACELLULAR-MATRIX ASSEMBLY
MONOCLONAL-ANTIBODY TO FIBRONECTIN WHICH INHIBITS EXTRACELLULAR-MATRIX ASSEMBLY
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DOI：
10.1016/0014-5793(87)81255-3
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发表时间：
1987-06-08
期刊：
影响因子：
3.5
通讯作者：
KOTELIANSKY, VE
中科院分区：
文献类型：
--
作者：
CHERNOUSOV, MA;FAERMAN, AI;KOTELIANSKY, VE
纤连蛋白特异性单克隆抗体L8显示出抑制纤连蛋白掺入成纤维细胞外基质。抗体L8不能与明胶复合的纤连蛋白相互作用。结果表明，存在一个特定的网站上的纤连蛋白分子发挥关键作用的组装纤连蛋白细胞外基质。该位点位于胶原结合结构域附近。
A monoclonal antibody L8 specific to fibronectin was shown to inhibit fibronectin incorporation into the fibroblast extracellular matrix. Antibody L8 could not interact with fibronectin complexed with gelatin. The results suggest the existence of a specific site on the fibronectin molecule playing a critical role in the assembly of the fibronectin extracellular matrix. This site is located near the collagen-binding domain.