Two new compounds with anti-inflammatory activity from Alangium chinense
Two new compounds with anti-inflammatory activity from Alangium chinense
复制标题
八角枫中两种具有抗炎活性的新化合物
DOI：
10.1080/14786419.2020.1843033
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发表时间：
2020
影响因子：
2.2
通讯作者：
Jiachun Chen
中科院分区：
文献类型：
--
作者：
Yue Yue;Zhi;Jiachun Chen
从八角枫（Alangium chinense）的根中分离得到一个新的酚苷类化合物--八角枫苷A（chinensideA）（1）和一个新的巨豆甾烷苷类化合物--八角枫苷A（chinenionsideA）（2），以及12个已知化合物（3-14）。它们的结构推导的基础上，广泛的光谱分析和文献报道的数据比较。评价所有13种酚苷对脂多糖诱导的小鼠巨噬细胞RAW 264.7细胞的体外抗炎活性。化合物1、9和10潜在地抑制一氧化氮（NO）、前列腺素（PEG 2）、肿瘤坏死因子α（TNF-α）、白细胞介素1 β（IL-1β）和白细胞介素6（IL-6）的产生。化合物1（50 μM）显示出比雷公藤内酯醇（TPL，20 nm）更强的抗炎活性。图形摘要
Abstract A new phenolic glycoside, chinenside A (1), and a new megastigmane glycoside, chinenionside A (2), together with twelve known compounds (3-14), were isolated from the roots of Alangium chinense. Their structures were deduced on the basis of extensive spectroscopic analyses and comparison with data reported in the literature. The anti-inflammatory activity in vitro of all 13 phenolic glycosides was evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. The compounds 1, 9, and 10 potentially inhibited the productions of nitric oxide (NO), prostaglandin (PEG2), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6). Compound 1 (50 μM) showed stronger anti-inflammatory activity than Triptolide (TPL, 20 nm). Graphical Abstract